AagingBase: Database of anti-aging peptides
A manually curated comprehensive database for anti-aging peptidesThe Literature info page of AAPeptide gives experimental informations of anti-aging peptides of AagingBase that were collected from scholarly articles and patents. Users can find the data in a filterable and sortable table. To obtain further details, refer to the Help page.
| AAP_ID | Reported name | ID | Year | Origin | Source | Experiment type | Cell lines/Animal model | Condition addressed | Bioactivity |
|---|---|---|---|---|---|---|---|---|---|
| AAPeptide261 | Tmem100 mutant polypeptide | US 11066455 B2 | 2021 | Natural | Mus musculus | In vivo | Mice | Pain occuring with aging | Enhances TRPA1 Activity |
| AAPeptide262 | Tmem100 mutant polypeptide | US 11066455 B2 | 2021 | Natural | Human | In vivo | Mice | Pain occuring with aging | Enhances TRPA1 Activity |
| AAPeptide263 | Water-soluble royal jelly protein (WSRJP) | NA | 2021 | Natural | Apis mellifera | In vitro | Human monocytic leukemia cell line U3-1 | Anti-aging ingredient of functional food | Protects cultured human cells against oxidative stress-induced cell death |
| AAPeptide264 | NA | US 2021/0017240 A1 | 2021 | Natural | Sunflower seed | In vitro | Human A549 cells | Oxidative stress, Anti-aging component of functional food | Reduces blood pressure, inflammation, Enhances immune activity, Decreases reactive oxidants, Induces vasodilation, Improves, Reduces the activity of angiotensin converting enzyme (ACE), Activates NAD(P)H:quinone reductase (QR), Reduces expression of mRNA for renin, Induces a drug-metabolizing enzyme, Activates nuclear factor erythroid 2 (NFE2)-related factor 2 (Nrf2) |
| AAPeptide265 | TELODIN (DKY21) | US 11365217 B2, US 11246818 B2 | 2021,2022 | Natural | Human | In vitro, In vivo | Human cervical carcinoma cells (Hela), 3-6 month old wild mice | Skin aging | Alleviates the respiratory dysfunction in mice, Reduces the expression of TPP1, the telomere shortening, Decreases the proportion of type II epithelial cells and pulmonary fibrosis caused by the overexpression of FBW7, Inhibits the telomere DNA damage caused by irradiation of X rays |
| AAPeptide266 | SOCS3 reduction peptide (SRP) | US 10906949 B2 | 2021 | NA | NA | In vivo | Rat model | Nervous system injuries (spinal cord injury (SCI)) caused by trauma or neurodegeneration or aging | Increases TBK1 and mitophagy adaptors in the spinal cord after SCI |
| AAPeptide267 | Repair peptide 4 | US 11260101 B2 | 2022 | Synthetic | NA | In vitro, In vivo | Mouse fibroblasts balb/c 3T3, Human umbilical vein endothelial cells (HUVEC), Chick embryo chorioallantoic membranes, Animal models of mice and rats | Wound repair of the skin tissue and nerve injury repair | A good wound repair and cell regeneration and proliferation product which can replace the recombinant bFGF |
| AAPeptide268 | Basa skin collagen peptide | US 11471395 B6 | 2022 | Natural | Pangasius bocourti | In vitro, In vivo | Human fibroblasts (CCD-966SK) | Skin aging | Promotes the expression of at least one gene of an Atg8 gene, a CCT2 gene, a CCT5 gene, a CCT6A gene, a CCT7 gene, a CCT8 gene, a Pink1 gene, a STIR gene, a Ubl-5 gene, a COL3A1 gene, a COL4A4 gene, an HAS2 gene and an HAS3 gene, Increases collagen content, Improves skin collagen density, skin moisture, Minimizs skin pores and reduces wrinkles |
| AAPeptide269 | NA | US 11246818 B2 | 2022 | Synthetic | NA | In vitro, Ex vivo | Primary human epidermal keratinocytes | Skin aging | Addresses skin imperfections associated with oxidative-stress, such as, skin complexion, pigmentation alterations, wrinkling and loss in skin density, tone and elasticity due to reduced amount of collagen or elastic fibers, loss in the structure of the extracellular matrix or structural lipids or DNA damage, Increases skin fragility and inflammatory response |
| AAPeptide270 | Klotho-derived peptide 1 | 35064106 | 2022 | Natural | Human | In vitro, In vivo | Normal rat kidney interstitial fibroblast (NRK-49F), Primary kidney tubular epithelial cells, Human proximal tubular cells (HKC-8), Rat primary cardiomyocytes, Rat primary cardiac fibroblasts, BALB/c mice | Chronic kidney disease | Restores Klotho expression by blocking H3K9 hypermethylation by inhibition of TGF-beta signalling, Binds to TβR2, Disrupts TGF-β and TβR2 engagement, and blocks Smad and MAPK signaling |
| AAPeptide271 | Repair peptide 3 | US 11260101 B2 | 2022 | Synthetic | NA | In vitro, In vivo | Mouse fibroblasts balb/c 3T3, Human umbilical vein endothelial cells (HUVEC), Chick embryo chorioallantoic membranes, Animal models of mice and rats | Wound repair of the skin tissue and nerve injury repair | A good wound repair and cell regeneration and proliferation product which can replace the recombinant bFGF |
| AAPeptide272 | Repair peptide 1 | US 11260101 B2 | 2022 | Synthetic | NA | In vitro, In vivo | Mouse fibroblasts balb/c 3T3, Human umbilical vein endothelial cells (HUVEC), Chick embryo chorioallantoic membranes, Animal models of mice and rats | Wound repair of the skin tissue and nerve injury repair | A good wound repair and cell regeneration and proliferation product which can replace the recombinant bFGF |
| AAPeptide273 | Basa skin collagen peptide | US 11471395 B7 | 2022 | Natural | Pangasius bocourti | In vitro, In vivo | Human fibroblasts (CCD-966SK) | Skin aging | Promotes the expression of at least one gene of an Atg8 gene, a CCT2 gene, a CCT5 gene, a CCT6A gene, a CCT7 gene, a CCT8 gene, a Pink1 gene, an STIR) gene, a Ubl-5 gene, a COL3A1 gene, a COL4A4 gene, an HAS2 gene and an HAS3 gene, Increases collagen content, Improves skin collagen density, skin moisture, minimizes skin pores and reduces wrinkles |
| AAPeptide274 | NA | US 11246818 B2 | 2022 | Synthetic | NA | In vitro, Ex vivo | Primary human epidermal keratinocytes, Primary human epidermal melanocytes | Skin aging | Addresses skin imperfections associated with oxidative-stress, such as, skin complexion, pigmentation alterations, wrinkling and loss in skin density, tone and elasticity due to reduced amount of collagen or elastic fibers, loss in the structure of the extracellular matrix or structural lipids or DNA damage, Increases skin fragility and inflammatory response |
| AAPeptide275 | Basa skin collagen peptide | US 11471395 B2 | 2022 | Natural | Pangasius bocourti | In vitro, In vivo | Human fibroblasts (CCD-966SK) | Skin aging, Anti aging component of functional food | Promotes the expression of at least one gene of an Atg8 gene, a CCT2 gene, a CCT5 gene, a CCT6A gene, a CCT7 gene, a CCT8 gene, a Pink1 gene, an STIR) gene, a Ubl-5 gene, a COL3A1 gene, a COL4A4 gene, an HAS2 gene and an HAS3 gene, Increases collagen content, Improves skin collagen density, skin moisture, minimizes skin pores and reduces wrinkles |
| AAPeptide276 | Repair peptide 2 | US 11260101 B2 | 2022 | Synthetic | NA | In vitro, In vivo | Mouse fibroblasts balb/c 3T3, Human umbilical vein endothelial cells (HUVEC), Chick embryo chorioallantoic membranes, Animal models of mice and rats | Wound repair of the skin tissue and nerve injury repair | A good wound repair and cell regeneration and proliferation product which can replace the recombinant bFGF |
| AAPeptide277 | NA | US 11246818 B2 | 2022 | Synthetic | NA | In vitro, Ex vivo | Primary human epidermal keratinocytes, Primary human epidermal melanocytes | Skin aging | Addresses skin imperfections associated with oxidative-stress, such as, skin complexion, pigmentation alterations, wrinkling and loss in skin density, tone and elasticity due to reduced amount of collagen or elastic fibers, loss in the structure of the extracellular matrix or structural lipids or DNA damage, Increases skin fragility and inflammatory response |
| AAPeptide278 | Basa skin collagen peptide | US 11471395 B5 | 2022 | Natural | Pangasius bocourti | In vitro, In vivo | Human fibroblasts (CCD-966SK) | Skin aging | Promotes the expression of at least one gene of an Atg8 gene, a CCT2 gene, a CCT5 gene, a CCT6A gene, a CCT7 gene, a CCT8 gene, a Pink1 gene, an STIR) gene, a Ubl-5 gene, a COL3A1 gene, a COL4A4 gene, an HAS2 gene and an HAS3 gene, Increases collagen content, Improves skin collagen density, skin moisture, minimizes skin pores and reduces wrinkles |
| AAPeptide279 | Basa skin collagen peptide | US 11471395 B3 | 2022 | Natural | Pangasius bocourti | In vitro, In vivo | Human fibroblasts (CCD-966SK) | Skin aging | Promotes the expression of at least one gene of an Atg8 gene, a CCT2 gene, a CCT5 gene, a CCT6A gene, a CCT7 gene, a CCT8 gene, a Pink1 gene, an STIR) gene, a Ubl-5 gene, a COL3A1 gene, a COL4A4 gene, an HAS2 gene and an HAS3 gene, Increases collagen content, Improves skin collagen density, skin moisture, minimizes skin pores and reduces wrinkles |
| AAPeptide280 | Klotho-derived peptide 6 | 35644285 | 2022 | Natural | Human | In vitro, In vivo | The mouse podocytes(HKC-8), Human proximal tubular cells (HK-2), Male CD-1 mice | Diabetic kidney disease (DKD) , (STZ-induced type 1 and genetic db/db type 2 diabetes) | Mitigates glomerular injury, Alleviates podocyte damage, Reverses albuminuria, Prevents glomerulosclerosis and interstitial fibrosis |