AagingBase: Database of anti-aging peptides
A manually curated comprehensive database for anti-aging peptidesThe Literature info page of AAPeptide gives experimental informations of anti-aging peptides of AagingBase that were collected from scholarly articles and patents. Users can find the data in a filterable and sortable table. To obtain further details, refer to the Help page.
| AAP_ID | Reported name | ID | Year | Origin | Source | Experiment type | Cell lines/Animal model | Condition addressed | Bioactivity |
|---|---|---|---|---|---|---|---|---|---|
| AAPeptide101 | NA | US 10195245 B2 | 2019 | Synthetic | NA | In vitro | Human skin keratinocytes (ATCC CRL-2404), SOR-300-FT Human Psoriasis Tissue Construct | Wound from aging | Stimulatory activities towards cell migration and effect wound repair |
| AAPeptide102 | NA | US 10195245 B2 | 2019 | Synthetic | NA | In vitro | Human skin keratinocytes (ATCC CRL-2404), SOR-300-FT Human Psoriasis Tissue Construct | Wound from aging | Stimulatory activities towards cell migration and effect wound repair |
| AAPeptide103 | NA | US 10195245 B2 | 2019 | Synthetic | NA | In vitro | Human skin keratinocytes (ATCC CRL-2404), SOR-300-FT Human Psoriasis Tissue Construct | Wound from aging | Stimulatory activities towards cell migration and effect wound repair |
| AAPeptide104 | NA | US 10195245 B2 | 2019 | Synthetic | NA | In vitro | Human skin keratinocytes (ATCC CRL-2404), SOR-300-FT Human Psoriasis Tissue Construct | Wound from aging | Stimulatory activities towards cell migration and effect wound repair |
| AAPeptide105 | Acetyl Tetrapeptide-2 | 30416406 | 2019 | Synthetic | NA | In vitro | HaCaT keratinocyte line | Skin aging | Stimulates the production of structural skin elements including collagen and elastin |
| AAPeptide106 | NA | US 11001607 B2, US 2019/0153030 A1 | 2021,2019 | Synthetic | NA | In vitro | Normal human fibroblasts (NHF) | Skin aging | Improves the mechanical properties of the skin, firmness/tonicity/elasticity/flexibility, Increases the density and volume of the skin, for a restructuring, healing effect, and/or to fight stretch marks, Stimulates the synthesis of collagens I and IV, fibronectin, elastin and hyaluronic acid |
| AAPeptide107 | Calcitonin receptor derived polypeptide | US 10294290 B2 | 2019 | Synthetic | NA | In vitro | PC12 (rat adrenal pheochromocytoma) cells, MC3T3-E1 (chondrocyte preosteoblast) cells, hFOB (human fetal osteoblast) cells | Bone aging | Increases the production of bone matrix in both differentiating and terminally differentiated cells, Increases the levels of osteocalcin |
| AAPeptide108 | Calcitonin receptor derived polypeptide | US 10294290 B2 | 2019 | Synthetic | NA | In vitro | PC12 (rat adrenal pheochromocytoma) cells, MC3T3-E1 (chondrocyte preosteoblast) cells , hFOB (human fetal osteoblast) cells | Bone aging | Increases the production of bone matrix in both differentiating and terminally differentiated cells, Increases the levels of osteocalcin |
| AAPeptide109 | Tetrapeptide-2 | US 2021/0093537 A1 | 2021,2019 | Synthetic | NA | In vitro, In vivo, Randomized clinical trial | Normal human keratinocytes (NHK), Dermal fibroblasts, 3T3-L1 adipocytes | Skin aging | Stimulates the synthesis of key cellular constituents for reinforcing the cutaneous barrier with respect to possible environmental and environmental aggressions and promote the moisturisation of the superficial layer of the epidermis, Increases elastin synthesis, Upregulates genes related to Collagen 1 synthesis |
| AAPeptide110 | NA | US 2019/0002505 A1 | 2019 | Synthetic | NA | In vitro, Ex vivo | Human monocyte cell line THP-1, Human hair follicle dermal papilla cells, Mouse Macrophage Cells (RAW 264.7), Mouse Bone Marrow-Derived Dendritic Cells | Alopecia caused by aging | Has immunostimulatory effect and therefore can be used as an immunostimulant, Can be used as an ingredient of cosmetics, quasi drugs, medicinal drugs, foods and drinks and dietary supplements intended to promote hair growth or regrowth |
| AAPeptide111 | NA | US 10233215 B2 | 2019 | Synthetic | NA | In vitro, Ex vivo | Human monocyte cell line THP-1, Human hair follicle dermal papilla cells, Mouse Macrophage Cells (RAW 264.7), Mouse Bone Marrow-Derived Dendritic Cells | Alopecia caused by aging | Has immunostimulatory effect and therefore can be used as an immunostimulant, Can be used as an ingredient of cosmetics, quasi drugs, medicinal drugs, foods and drinks and dietary supplements intended to promote hair growth or regrowth |
| AAPeptide112 | NA | US 2019/0142723 A1, US 10660839 B2 | 2020,2019 | Natural | Human and mouse | In vitro | Human melanocytes (HEMn cells) , Mouse melanoma (B16 cells), Human fibroblasts,Mouse melanoma (B16 cells), Normal human melanocytes (HEMn cells), Human keratinocytes | Skin aging | Treatment of spots and wrinkles , Anti-wrinkles and fine lines, Moisturizing,prevent and/or treat the default of complexion homogeneity, the loss of collagen in the skin extracellular matrix or for stimulating the synthesis of collagen to obtain a volumizing effect, he loss of skin hydration by improving the skin barrier and in an anti-aging, anti-wrinkles and fine lines treatment |
| AAPeptide113 | NA | US 2019/0343923 A1, US 10314888 B2 | 2019 | Natural | Human | In vitro | Human Mesenchymal Stem Cells (Fibrocytes), Dog Pancreas (NAT-CRT) | Skin aging | Eliminates wrinkles and/or fine lines, Tissue repair and reconstruction, Treates wound in a patient suffering from delayed wound healing |
| AAPeptide114 | NA | US 2019/0343923 A1, US 10314888 B2 | 2019 | Natural | Human | In vitro | Human Mesenchymal Stem Cells (Fibrocytes), Dog Pancreas (NAT-CRT) | Skin aging | Eliminates wrinkles and/or fine lines, Tissue repair and reconstruction, Treates wound in a patient suffering from delayed wound healing |
| AAPeptide115 | NA | US 2019/0343923 A1, US 10314888 B2 | 2019 | Natural | Human | In vitro | Human Mesenchymal Stem Cells (Fibrocytes), Dog Pancreas (NAT-CRT) | Skin aging | Eliminates wrinkles and/or fine lines, Tissue repair and reconstruction, Treates wound in a patient suffering from delayed wound healing |
| AAPeptide116 | NA | US 2019/0343923 A1, US 10314888 B2 | 2019 | Natural | Human | In vitro | Human Mesenchymal Stem Cells (Fibrocytes), Dog Pancreas (NAT-CRT) | Skin aging | Eliminates wrinkles and/or fine lines, Tissue repair and reconstruction, Treates wound in a patient suffering from delayed wound healing |
| AAPeptide117 | LCE6A | US 11479580 B2, US 2019/0010191 A1 | 2022,2019 | Natural | Human | In vitro, Ex vivo | Psoriatic Human Epidermis, Human abdominal skin | Skin aging | Reinforces the barrier function of the epidermis, Treats the signs of skin dryness and prevent and/or treat disorders of the barrier function or the weakening of the epidermis |
| AAPeptide118 | EPO-peptide variant | US 10456346 B2, US 11197812 B2, US 2019/0254948 A1 | 2021,2019 | Natural | Human | Randomized clinical trial | NA | Skin aging | Improves the appearance of the skin |
| AAPeptide119 | NA | US 2019/0142723 A1 | 2019 | Natural | Human and mouse | In vitro | Human melanocytes (HEMn cells), Mouse melanoma (B16 cells), Human fibroblasts | Skin aging | Treates spots, fine lines and wrinkles, Has moisturizing properties |
| AAPeptide120 | Tetrapeptide | US 10376557 B2 | 2019 | Synthetic | Human | In vitro | Human dermal fibroblast, Human skin epithelial cells (CRL-2592) | Skin aging | Repaires damaged skin, Wound healing |