AagingBase | Database of anti-aging peptide

AagingBase: Database of anti-aging peptides A manually curated comprehensive database for anti-aging peptides

Peptide Card for AAPeptide109

The Peptide Card page for AAPeptide109 gives textual and graphical visualizations of the properties of AAPeptide109. The users can find all the literature informations collected from scholarly articles and patents and the calculated physicochemical informations. There are also graphical representations hydropathy values, amino acid compositions and frequencies, atomic compositions and secondary structure fractions of AAPeptide109.
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AAP ID	AAPeptide109
Peptide name	Tetrapeptide-2
PubMed/Patent ID	US 2021/0093537 A1,US 2019/0038539 A1
Origin	Synthetic
Source of Origin	NA
Condition addressed	Skin aging
Experiment type	In vitro, In vivo, Randomized clinical trial
Cell lines/Animal model	Normal human keratinocytes (NHK), Dermal fibroblasts, 3T3-L1 adipocytes
Intervention	Cells were treated with the peptide, Topical application of the formulation on a patient undergoing Coolsculpting,Cells were treated with the peptide
Experiment methods	Gene expression profiling, Macrophage Clustering, qRT-PCR, Immunofluorescence, Transglutaminase activity, DNA-Array, Fluorescence immunohistology, ELISA
Patient group	Women between 25 and 65 years of age to assess the efficacy of the regenerating body complex (RBC), Caucasian females of 54 years old
Markers used	filaggrin, loricrin, involucrin(markers of epidermal maturation), KLK5 (kallikrein 5)(desquamation marker)
Mechanism of action	Stimulates the synthesis of key cellular constituents for reinforcing the cutaneous barrier with respect to possible environmental and environmental aggressions and promote the moisturisation of the superficial layer of the epidermis, Increases elastin synthesis, Upregulates genes related to Collagen 1 synthesis

Molecular weight	522.638
Peptide length	4
Instability index	0.775
Aromaticity	0.250
Aliphaticity	0.000
Reduced molecular extinction coeffecient	0
Oxidized molecular extinction coeffecient	0
Isoelectric point	10.003
Composition of positively charged residues	0.500
Composition of negatively charged residues	0.000
Composition of neutral charged residues	0.500
Composition of residues polar residues	0.250
Composition of residues non-polar residues	0.250
Composition of residues having cyclic side chain	0.000
Composition of acidic residues	0.000
Composition of basic residues	0.500
Composition of residues having cyclic side chain	0.000
Composition of hydroxylic residues	0.250
Composition of residue in buried solvent accessibility	0.250
Composition of residue in exposed solvent accessibility	0.500
Composition of residue in intermediate solvent accessibility	0.250

AAPeptide109 :

KTFK

Amino acid data

ProtScale

Disclaimer: Hydropathy plot is not available for AAPeptide109 as the peptide length is less than 9 amino acid residues

Atomic information

3D Structure

Structural Representation of AAPeptide109

Amino acid data

Secondary structure fraction