AagingBase: Database of anti-aging peptides
A manually curated comprehensive database for anti-aging peptidesThe Literature info page of AAPeptide gives experimental informations of anti-aging peptides of AagingBase that were collected from scholarly articles and patents. Users can find the data in a filterable and sortable table. To obtain further details, refer to the Help page.
| AAP_ID | Reported name | ID | Year | Origin | Source | Experiment type | Cell lines/Animal model | Condition addressed | Bioactivity |
|---|---|---|---|---|---|---|---|---|---|
| AAPeptide001 | Neuropeptide Y | 11495681 | 2001 | Natural | NA | In vivo | BALB/c mice | Immunosenescenece | Modulates NK activity, with influence on the intracellular cAMP levels |
| AAPeptide002 | Tetrapeptide | 21692860, US 2020/0093799 A1 | 2011,2020 | Synthetic | NA | In vitro, In vitro, Randomized clinical trial | Primary human foreskin fibroblasts, Normal human dermal fibroblasts (NHDF) | Skin aging | Increases the formation of procollagen, HAS-1 and fibronectin, Stimulates the production of extracellular matrix components in skin or epithelial cells |
| AAPeptide003 | Lipoic acid (LA)-peptide conjugate, | 24090916, US 9856290 B2, US 10071043 B2 | 2013,2018 | Natural | Human | In vitro | Human Dermal Fibroblast (HDF), Human Dermal Fibroblasts (KMST-6), Mouse melanoma B16F10 cells | Melanogenesis, Skin aging | Increases ECM secretion (elastin and fibronectin), Enhances skin barrier function, Skin hydration, Possesses the ability to enhance dermal remodeling by triggering cellular processes, such as increasing ECM production |
| AAPeptide004 | Octanoyl Carnosine,Carnosine | 25055965, US 11331305 B2, US 2020/0093799 A1 | 2020,2022,2014 | Natural | Human | In vitro, In vivo, Randomized clinical trial | BALB/c mice, Normal human dermal fibroblasts (NHDF) | D-galactose induced aging, Anti aging component of functional food, Skin aging | Attenuates the oxidative stress, Improves spatial memory and learning dysfunctions, Stimulates the production of extracellular matrix components in skin or epithelial cells |
| AAPeptide005 | GV1001 | 24439482, US 10898540 B2, US 2019/0142894 A1, 34649386, US 10227382 B2 | 2021,2014,2019 | Natural | Human | In vitro, In vivo | Neural Stem Cells from rodent embryonic brains, Primary cultured cortical neurons, Human neural stem cells (H9 hESC-derived),Male Sprague-Dawley rats, B6 transgenic mice | Cell aging, Neurotoxicity, Cell loss and senescence, Anti aging component of functional food, Focal cerebral ischemia-reperfusion injury (IRI) | Treats diseases induced by an abnormal decrease in telomerase activity, cellular senescence, and diseases associated with the loss of nervous cells and regeneration capability, Protectes NSCs, Improves mitochondrial function, Increases the levels of diverse intracellular proteins, such as elongation factor 1-delta, heat shock protein 90α, and ezrin in OGD/R-injured NCSs |
| AAPeptide006 | Argireline | 30416406, 24644551, US 10045925 B2 | 2018,2014,2019 | Synthetic | NA | In vitro, Randomized clinical trial | HaCaT keratinocyte line, Human embryonic kidney HEK-293 cell line, Human neuroblastoma IMR-32 cell line, Human primary skin fibroblasts | Cellular proliferation, Skin aging | Simulates the action of transcription factor FOXO3a, Protectes DNA and maintains cellular homeostasis, Blocks Ca2+ dependent neurotransmitter release (acetylcholine), Skin brightening, Improves hydration and firmness |
| AAPeptide007 | Asn-Trp (NW) | 25055965 | 2014 | Synthetic | NA | In vivo | BALB/c mice | D-galactose induced aging, Anti aging component of functional food | Attenuates oxidative stress, Improves spatial memory and learning dysfunctions |
| AAPeptide008 | Hexapeptide-11 | US 11052032 B2, 25974626, US 2019/0038539 A1 | 2015,2021,2019 | Synthetic | NA | In vitro, In vivo, Randomized clinical trial | Human lung embryonic (IMR90 cells), Human newborn foreskin (BJs) fibroblasts, Dermal fibroblasts, 3T3-L1 adipocytes | Aging associated skin laxity, Oxidative stress induced cellular senescence | Induces the activity of extracellular MMPs, Activates the MMP-2/MMP-9 metalloproteinases and suppresses fibroblasts migration, Stimulates autophagy, promotes dose and time-dependent activation of proteasome, autophagy, chaperones and antioxidant responses related genes, Improves skin laxity, texture, or crepiness or body contouring |
| AAPeptide009 | Petides from donkey milk | 27325462 | 2016 | Natural | Donkey milk | NA | NA | Anti aging component of functional food | Shows anti-oxidant activity |
| AAPeptide010 | Petides from donkey milk | 27325462 | 2016 | Natural | Donkey milk | NA | NA | Anti aging component of functional food | Shows anti-oxidant activity |
| AAPeptide011 | Humanin | 35086467, 26990160 | 2022,2016 | Natural | Human | In vitro, In vivo | Mice,Human retinal pigment epithelial (hRPE) cells | Cell death, Late-onset Hypogonadism | Protects RPE Cells From Oxidative Stress–Induced Cell Death, Re-establishes Mitochondrial function and biogenesis, Can treat age-related macular degeneration(AMD), maintain testicular health |
| AAPeptide012 | Acein | 27027724 | 2016 | Synthetic | NA | In vitro, In vivo | Guinea pigs, Sprague–Dawley rats | Aging induced by senescent cells development | Able to induce in vivo and in vitro stimulation of dopamine release from rat brain tissue |
| AAPeptide013 | Dipeptide Tyr-Ala | 26987062 | 2016 | Natural | Maize | In vivo | C. elegans(N = 20 per group) | Oxidative/heat stress | Regulates the expression of the aging-associated genes daf-2, daf-16, sod-3, skn-1 and hsp-16 2 |
| AAPeptide014 | Apelin | 29117554, 30061698 | 2017,2018 | Natural | Human | In vitro, In vivo, Ex vivo | Human myoblasts, Human coronary artery endothelial cells (HCAECs), Human cardiac fibroblasts (HCFs), C57BL/6 mice | Sarcopenia, Age dependant reduction of apelinergic axis | Targets muscle stem cells to enhance muscle regeneration, Promotes mitochondriogenesis and protein synthesis, Reverses age-associated sarcopenia and ameliorates age-associated impairment of cardiovascular and behavioral functions |
| AAPeptide015 | PYP1‑5 | 27878236 | 2017 | Natural | Pyropia yezoensis | In vitro | Human skin fibroblast cell line Hs27 | Skin aging | Promotes type I collagen synthesis, Increases elastin expression, Decreases MMP-1 expression and increases TIMP-1 and -2 expression, Increases the expression of specificity protein 1 (Sp1) transcription factor via the TGF-β/Smad signaling pathway |
| AAPeptide016 | hPTH(1-34) | 27887949 | 2017 | Synthetic | NA | In vivo | Sprague Dawley rats | Osteoporosis | Elevates the bone mass |
| AAPeptide017 | PDGF peptide fragment | US 9999649 B2 | 2018 | Natural | Human | In vitro | Human dermal fibroblast cells | Skin aging | Increases hyaluronic acid production |
| AAPeptide018 | NA | US 10045925 B2 | 2018 | Synthetic | NA | In vitro, Randomized clinical trial | Adult human skin (HaCaT) | Skin aging | Skin brightening, Improves hydration and firmness |
| AAPeptide019 | NA | US 2018/0325794 A1, EP 3366694 A1, US 10478392 B2 | 2018,2019 | Natural | Human | In vitro | Human epidermal keratinocytes | Skin aging | Inhibites skin-wrinkle formation |
| AAPeptide020 | P-113 peptide | US 10596095 B2, US 2018/0369115 A1 | 2018,2020 | Natural | Human | In vitro | Rat basophilic leukemia cell line (RBL-2H3) | Skin aging | Prevents wrinkle formation |