AagingBase | Database of anti-aging peptide

AagingBase: Database of anti-aging peptides A manually curated comprehensive database for anti-aging peptides

Peptide Card for AAPeptide006

The Peptide Card page for AAPeptide006 gives textual and graphical visualizations of the properties of AAPeptide006. The users can find all the literature informations collected from scholarly articles and patents and the calculated physicochemical informations. There are also graphical representations hydropathy values, amino acid compositions and frequencies, atomic compositions and secondary structure fractions of AAPeptide006.
To obtain further details, refer to the Help page.

AAP ID	AAPeptide006
Peptide name	Argireline
PubMed/Patent ID	30416406,24644551,US 10045925 B2
Origin	Synthetic
Source of Origin	NA
Condition addressed	Cellular proliferation, Skin aging
Experiment type	In vitro, Randomized clinical trial
Cell lines/Animal model	HaCaT keratinocyte line, Human embryonic kidney HEK-293 cell line, Human neuroblastoma IMR-32 cell line, Human primary skin fibroblasts
Intervention	Cells were treated with the peptide, Topical application of the formulation,Cells were treated with the peptide
Experiment methods	MTT cytotoxicity assay, AFM, qPCR, Actin filaments visualisation, EZ4U cell proliferation assay, Assessment of face wrinkles, skin radiance/luminosity and skin lightness, GSH, LDH Antioxidant enzyme activity, Stability Testing
Patient group	Female subjects, aged 35-55 years
Markers used	Lactate dehydrogenase (LDH, a general cytotoxicity marker)
Mechanism of action	Simulates the action of transcription factor FOXO3a, Protectes DNA and maintains cellular homeostasis, Blocks Ca2+ dependent neurotransmitter release (acetylcholine), Skin brightening, Improves hydration and firmness

Molecular weight	847.940
Peptide length	6
Instability index	145.567
Aromaticity	0.000
Aliphaticity	0.000
Reduced molecular extinction coeffecient	0
Oxidized molecular extinction coeffecient	0
Isoelectric point	6.243
Composition of positively charged residues	0.333
Composition of negatively charged residues	0.333
Composition of neutral charged residues	0.333
Composition of residues polar residues	0.167
Composition of residues non-polar residues	0.167
Composition of residues having cyclic side chain	0.000
Composition of acidic residues	0.333
Composition of basic residues	0.333
Composition of residues having cyclic side chain	0.000
Composition of hydroxylic residues	0.000
Composition of residue in buried solvent accessibility	0.000
Composition of residue in exposed solvent accessibility	0.500
Composition of residue in intermediate solvent accessibility	0.167

AAPeptide006 :

EEMQRR

Amino acid data

ProtScale

Disclaimer: Hydropathy plot is not available for AAPeptide006 as the peptide length is less than 9 amino acid residues

Atomic information

3D Structure

Structural Representation of AAPeptide006

Amino acid data

Secondary structure fraction