AagingBase: Database of anti-aging peptides
A manually curated comprehensive database for anti-aging peptidesThe Literature info page of AAPeptide gives experimental informations of anti-aging peptides of AagingBase that were collected from scholarly articles and patents. Users can find the data in a filterable and sortable table. To obtain further details, refer to the Help page.
| AAP_ID | Reported name | ID | Year | Origin | Source | Experiment type | Cell lines/Animal model | Condition addressed | Bioactivity |
|---|---|---|---|---|---|---|---|---|---|
| AAPeptide201 | Acetylcholine receptor-binding peptide | US 2020/0123199 A1 | 2020 | Synthetic | NA | NA | NA | Skin aging | Suppress secretion of acetylcholine, Exhibits an excellent wrinkle ameliorating effect |
| AAPeptide202 | Acetylcholine receptor-binding peptide | US 2020/0123199 A1 | 2020 | Synthetic | NA | NA | NA | Skin aging | Suppress secretion of acetylcholine, Exhibits an excellent wrinkle ameliorating effect |
| AAPeptide203 | Acetylcholine receptor-binding peptide | US 2020/0123199 A1 | 2020 | Synthetic | NA | NA | NA | Skin aging | Suppress secretion of acetylcholine, Exhibits an excellent wrinkle ameliorating effect |
| AAPeptide204 | Acetylcholine receptor-binding peptide | US 2020/0123199 A1 | 2020 | Synthetic | NA | NA | NA | Skin aging | Suppress secretion of acetylcholine, Exhibits an excellent wrinkle ameliorating effect |
| AAPeptide205 | Acetylcholine receptor-binding peptide | US 2020/0123199 A1 | 2020 | Synthetic | NA | NA | NA | Skin aging | Suppress secretion of acetylcholine, Exhibits an excellent wrinkle ameliorating effect |
| AAPeptide206 | Acetylcholine receptor-binding peptide | US 2020/0123199 A1 | 2020 | Synthetic | NA | NA | NA | Skin aging | Suppress secretion of acetylcholine, Exhibits an excellent wrinkle ameliorating effect |
| AAPeptide207 | Acetylcholine receptor-binding peptide | US 2020/0123199 A1 | 2020 | Synthetic | NA | NA | NA | Skin aging | Suppress secretion of acetylcholine, Exhibits an excellent wrinkle ameliorating effect |
| AAPeptide208 | Acetylcholine receptor-binding peptide | US 2020/0123199 A1 | 2020 | Synthetic | NA | NA | NA | Skin aging | Suppress secretion of acetylcholine, Exhibits an excellent wrinkle ameliorating effect |
| AAPeptide209 | Acetylcholine receptor-binding peptide | US 2020/0123199 A1 | 2020 | Synthetic | NA | NA | NA | Skin aging | Suppress secretion of acetylcholine, Exhibits an excellent wrinkle ameliorating effect |
| AAPeptide210 | Pentapeptide-18 | 31937863 | 2020 | Synthetic | NA | In vitro | Human melanoma cell line (MNT-1), RAW 264.7, Human dermal fibroblasts (NHDF) | Melanogenesis | Inhibits melanin synthesis |
| AAPeptide211 | α-Neoendorphin (NEP) | 32526201 | 2020 | Natural | Human | In vitro | Human dermal fibroblast cells | Skin aging and autophagy activation | Activates the kappa opioid receptor and exhibits certain anti-aging and anti-wrinkling effects, Increases the type I procollagen production, while decreasing MMP-1, MMP-2, and MMP-9 activities, Reduces UVB-induced photoaging by activating autophagy |
| AAPeptide212 | Keramin2 peptide | US 2020/0289526 A1 | 2020 | Synthetic | NA | In vitro | HaCaT keratinocytes, Human Hair Dermal Papilla Cells (HHDP Cells) | Skin aging | Has excellent physiological activities such as preventing hair loss, promoting hair growth, promoting cell growth, etc , but also has excellent stability in water and skin permeability |
| AAPeptide213 | Kisspeptin-E | 33182726 | 2020 | Synthetic | NA | In vitro, Ex vivo | Human dermal fibroblast (Hs68) | Skin aging | Suppresses UV-induced 11β-HSD1 stimulation leading to a regulation of skin aging related genes and rescues the skin structure against UV irradiation, Inhibits the gene expression of stress related skin aging |
| AAPeptide214 | Kisspeptin 10 | 33182726 | 2020 | Synthetic | NA | In vitro, Ex vivo | Human dermal fibroblast (Hs68) | Skin aging | Suppresses UV-induced 11β-HSD1 stimulation leading to a regulation of skin aging related genes and rescues the skin structure against UV irradiation, Inhibits the gene expression of stress related skin aging |
| AAPeptide215 | ATF3 Protein-Binding Peptide | US 2021/0355164 A1 | 2021 | Synthetic | NA | In vitro, In vivo | HepG2 cells, C57BL/6J mice | Skin aging | Addresses oxidative stress, skin diseases, skin aging, damage caused by UV irradiation |
| AAPeptide216 | NA | US 11103436 B2 | 2021 | Synthetic | NA | In vitro | Mouse fibroblast NIH3T3 cell line, Human keratinocyte HaCaT cell line | Skin aging, Anti-aging component of functional food | Improves skin condition, Treats skin condition |
| AAPeptide217 | Agaricus blazei polypeptide (ABp) | 33200472 | 2021 | Natural | Agaricus blazei | In vivo | ICR mice | D-Galactose induced aging | Improves the oxidative stress injury and exerts an anti-aging effect |
| AAPeptide218 | Pine nut protein hydrolysate (PNPH)-P8 | 33289247 | 2021 | Natural | Pinus yunnanensis Franch | In vitro, In vivo | HepG2, SPF Kunming mice | D-Galactose induced aging | Have potential application prospects in the field of natural antioxidants and anti-aging functional foods |
| AAPeptide219 | Velvet antler polypeptide | 34645090 | 2021 | Natural | Velvet antler | In vivo | ICR mice | D-Galactose induced aging | Promotes the expression of CPT1A and ACOX1 by activating PPAR α, Regulates the intestinal flora of aging mice, thereby improving lipid metabolism in aging mice, Increases ATP and reduces the expression of APOE by reducing fatty acid content in the brain of aging mice, thereby improving the cognitive impairment caused by aging, Improving learning ability, and protecting neurons |
| AAPeptide220 | Water-soluble royal jelly protein (WSRJP) | NA | 2021 | Natural | Apis mellifera | In vitro | Human monocytic leukemia cell, line U3-1 | Anti aging ingredient of functional food | Protects cultured human cells against oxidative stress-induced cell death |