AagingBase: Database of anti-aging peptides
A manually curated comprehensive database for anti-aging peptidesThe Literature info page of AAPeptide gives experimental informations of anti-aging peptides of AagingBase that were collected from scholarly articles and patents. Users can find the data in a filterable and sortable table. To obtain further details, refer to the Help page.
| AAP_ID | Reported name | ID | Year | Origin | Source | Experiment type | Cell lines/Animal model | Condition addressed | Bioactivity |
|---|---|---|---|---|---|---|---|---|---|
| AAPeptide141 | NA | US 2019/0153045 A1 | 2019 | Natural | Oryza sativa | In vitro, Ex vivo | Skin fibroblasts derived healthy Caucasian females of different ages, Adult dermal fibroblasts, Human skin explants | Skin aging | Increases the production of elastic fibers |
| AAPeptide142 | NA | US 2019/0153045 A1, US 10844101 B2 | 2020,2019 | Natural | Oryza sativa | In vitro, Ex vivo | Adult dermal fibroblast,Skin fibroblasts derived healthy Caucasian females of different ages, Adult dermal fibroblasts, Human skin explants | Skin aging | Increases production of elastic fibers by stromal cells isolated from human heart,Treating facial lines and wrinkles, Stimulates proliferation and migration of dermal fibroblasts into an area of skin |
| AAPeptide143 | NA | US 2019/0153045 A1 | 2019 | Natural | Oryza sativa | In vitro, Ex vivo | Skin fibroblasts derived healthy Caucasian females of different ages, Adult dermal fibroblasts, Human skin explants | Skin aging | Increases production of elastic fibers by stromal cells isolated from human heart,Treating facial lines and wrinkles, Stimulates proliferation and migration of dermal fibroblasts into an area of skin |
| AAPeptide144 | NA | US 2019/0153045 A1, US 10844101 B2 | 2020,2019 | Natural | Oryza sativa | In vitro, Ex vivo | Adult dermal fibroblast,Skin fibroblasts derived healthy Caucasian females of different ages, Adult dermal fibroblasts, Human skin explants | Skin aging | Increases production of elastic fibers by stromal cells isolated from human heart,Treating facial lines and wrinkles, Stimulates proliferation and migration of dermal fibroblasts into an area of skin |
| AAPeptide145 | NA | US 2019/0153045 A1 | 2019 | Natural | Oryza sativa | In vitro, Ex vivo | Skin fibroblasts derived healthy Caucasian females of different ages, Adult dermal fibroblasts, Human skin explants | Skin aging | Increases production of elastic fibers by stromal cells isolated from human heart,Treating facial lines and wrinkles, Stimulates proliferation and migration of dermal fibroblasts into an area of skin |
| AAPeptide146 | NA | US 2019/0153045 A1 | 2019 | Natural | Oryza sativa | In vitro, Ex vivo | Skin fibroblasts derived healthy Caucasian females of different ages, Adult dermal fibroblasts, Human skin explants | Skin aging | Increases production of elastic fibers by stromal cells isolated from human heart,Treating facial lines and wrinkles, Stimulates proliferation and migration of dermal fibroblasts into an area of skin |
| AAPeptide147 | Casein‐derived peptide | 30592315 | 2019 | Natural | Buffalo milk | Ex vivo | Skin fibroblasts | Cell aging | Shows antiaging effect in prolonged serial passaged fibroblast cells, Causes activation and transmigration of Nrf2 for maintaining homeostasis, Rejuvenates the aged fibroblast cells by weakening the effects of the senescent associated secretory phenotype |
| AAPeptide148 | Calcitonin receptor derived polypeptide | US 10294290 B2 | 2019 | Synthetic | NA | In vitro | PC12 (rat adrenal pheochromocytoma) cells, MC3T3-E1 (chondrocyte preosteoblast) cells, hFOB (human fetal osteoblast) cells | Bone aging | Increases the production of bone matrix in both differentiating and terminally differentiated cells, Increases the levels of osteocalcin |
| AAPeptide149 | Calcitonin receptor derived polypeptide | US 10294290 B2 | 2019 | Synthetic | NA | In vitro | PC12 (rat adrenal pheochromocytoma) cells, MC3T3-E1 (chondrocyte preosteoblast) cells, hFOB (human fetal osteoblast) cells | Bone aging | Increases the production of bone matrix in both differentiating and terminally differentiated cells, Increases the levels of osteocalcin |
| AAPeptide150 | 5-YHEDA | 31921964 | 2019 | Synthetic | NA | In vitro, In vivo | Neuroblastoma cell line SH-sy5y, Human vascular endothelial cells (HECV) | Brain aging | Protects cells by reducing radicals, Binds LDLR and thus cross the BBB to enter the brain |
| AAPeptide151 | LDLR binding site containg 5-YHEDA (bs-5-YHEDA) | 31921964 | 2019 | Synthetic | NA | In vitro, In vivo | Neuroblastoma cell line SH-sy5y, Human vascular endothelial cells (HECV) | Brain aging | Relieves senescence-induced inflammation |
| AAPeptide152 | Neo-Pep | US 2020/0010524 A1 | 2020 | Natural | Human | In vitro | Human foreskin fibroblast | Skin aging | Improves the appearance of wrinkles, skin flexibility and elasticity |
| AAPeptide153 | Ginsentide TP1 | US 2020/0277343 A1, US 11174298 B2 | 2021,2020 | Natural | Panax ginseng | In vitro | Human umbilical vein endothelial cells (HUVEC) | Skin aging | Reduces apoptosis signaling pathways and reduced cell adhesion pathways, Promotes adaptation of endothelials cells to hypoxic stress, Reduces unfolded proteins in cardiomyocyte, vascular smooth muscle cells, and myocytes, Reduces reactive oxygen species production in hypoxic endothelial cells, Prevents telomere shortening, Prevents oxidative stress induced aging |
| AAPeptide154 | NA | US 10799442 B2 | 2020 | Synthetic | NA | In vitro, Randomized clinical trial | Human Epidermal Keratinocytes from Adult (HEKa), Human Keratinocyte (HaCaT) cell line, Reconstructed Human Epidermal Tissue (RHE) | Skin aging | Decreases miRNA expression in human keratinocytes, Increases the levels of transcription factors involved in the self-renewing processes of the skin |
| AAPeptide155 | NA | US 10799442 B2 | 2020 | Synthetic | NA | In vitro, Randomized clinical trial | Human Epidermal Keratinocytes from Adult (HEKa), Human Keratinocyte (HaCaT) cell line, Reconstructed Human Epidermal Tissue (RHE) | Skin aging | Decreases miRNA expression in human keratinocytes, Increases the levels of transcription factors involved in the self-renewing processes of the skin |
| AAPeptide156 | NA | US 10799442 B2 | 2020 | Synthetic | NA | In vitro, Randomized clinical trial | Human Epidermal Keratinocytes from Adult (HEKa), Human Keratinocyte (HaCaT) cell line, Reconstructed Human Epidermal Tissue (RHE) | Skin aging | Decreases miRNA expression in human keratinocytes, Increases the levels of transcription factors involved in the self-renewing processes of the skin |
| AAPeptide157 | NA | US 10799442 B2 | 2020 | Synthetic | NA | In vitro, Randomized clinical trial | Human Epidermal Keratinocytes from Adult (HEKa), Human Keratinocyte (HaCaT) cell line, Reconstructed Human Epidermal Tissue (RHE) | Skin aging | Decreases miRNA expression in human keratinocytes, Increases the levels of transcription factors involved in the self-renewing processes of the skin |
| AAPeptide158 | Rice protein hydrolysates | 32955075 | 2020 | Natural | Rice | In vitro | Human epidermal melanocyte (PIG1) cells | Melanogenesis | Reduces the melanin content, tyrosinase activity and ROS levels induced by UVB |
| AAPeptide159 | Nokkin peptide | US 2020/0289526 A1 | 2020 | Synthetic | NA | In vitro | HaCaT keratinocytes, Human Hair Dermal Papilla Cells (HHDP Cells) | Skin aging | Has excellent physiological activities such as preventing hair loss, promoting hair growth, promoting cell growth, etc, Has excellent stability in water and skin permeability |
| AAPeptide160 | NA | US 10799442 B2 | 2020 | Synthetic | NA | In vitro, Randomized clinical trial | Human Epidermal Keratinocytes from Adult (HEKa), Human Keratinocyte (HaCaT) cell line, Reconstructed Human Epidermal Tissue (RHE) | Skin aging | Decreases miRNA expression in human keratinocytes and, as a result, increase the levels of transcription factors involved in the self-renewing processes of the skin |