AagingBase: Database of anti-aging peptides
A manually curated comprehensive database for anti-aging peptidesThe Literature info page of AAPeptide gives experimental informations of anti-aging peptides of AagingBase that were collected from scholarly articles and patents. Users can find the data in a filterable and sortable table. To obtain further details, refer to the Help page.
| AAP_ID | Reported name | ID | Year | Origin | Source | Experiment type | Cell lines/Animal model | Condition addressed | Bioactivity |
|---|---|---|---|---|---|---|---|---|---|
| AAPeptide161 | A. japonicus protein hydrolyzate (AjPH) | 32520032 | 2020 | Natural | Apostichopus japonicus | In vitro, In vivo | Rat pheochromocytoma cell line PC12, Caenorhabditis elegans (wild-type N2) , Escherichia coli (OP50 and NA22 | Anti aging component of functional food | Reduces the ROS level, Decreases the accumulation of age pigments and extends the adult lifespan, Shows anti-aging effect without sacrificing growth and reproduction" |
| AAPeptide162 | TRPV3 agonist peptide | US 10864152 B2 | 2020 | Synthetic | NA | In vitro | Human keratinocyte cell line (HaCaT) | Skin aging | Promotes the migration and/or proliferation of keratinocytes in the skin |
| AAPeptide163 | Biotin-conjugated GHRP-6 peptide (biotinyl-hexapeptide, BH) | 31861912 | 2020 | Synthetic | NA | In vitro, Randomized clinical trial | Human neonatal primary dermal fibroblast (hDFn), Human adult primary epidermal keratinocyte (HEKa) | Skin aging | Increases dermal collagen and epidermal protein expressiion |
| AAPeptide164 | S1300 | US 10800824 B2 | 2020 | Natural | Human | In vitro | Human foreskin fibroblast | Skin aging | Improves the appearance of wrinkles, skin flexibility and elasticity |
| AAPeptide165 | Acetylcholine receptor-binding peptide | US 2020/0123199 A1 | 2020 | Synthetic | NA | NA | NA | Skin aging | Suppresses secretion of acetylcholine, Exhibits an excellent wrinkle ameliorating effect |
| AAPeptide166 | Rice protein hydrolysates | 32955075 | 2020 | Natural | Rice | In vitro | Human epidermal melanocyte (PIG1) cells | Melanogenesis | Reduces the melanin content, tyrosinase activity and ROS levels induced by UVB |
| AAPeptide167 | Rice protein hydrolysates | 32955075 | 2020 | Natural | Rice | In vitro | Human epidermal melanocyte (PIG1) cells | Melanogenesis | Reduces the melanin content, tyrosinase activity and ROS levels induced by UVB |
| AAPeptide168 | NA | US 10799442 B2 | 2020 | Synthetic | NA | In vitro, Randomized clinical trial | Human Epidermal Keratinocytes from Adult (HEKa), Human Keratinocyte (HaCaT) cell line, Reconstructed Human Epidermal Tissue (RHE) | Skin aging | Decreases miRNA expression in human keratinocytes and, as a result, increase the levels of transcription factors involved in the self-renewing processes of the skin |
| AAPeptide169 | PEP | 32419813 | 2020 | Natural | Trapa japonica | In vitro, Randomized clinical trial | Human keratinocyte-derived (HaCaT) cells, Human dermal fibroblasts (HDFs) | Skin aging | Exerts an effect on cell proliferation and collagen synthesis by decreasing the mRNA expression of TNF-α-induced MMP-1 and MMP-9 in HDFs, Shows potential as an anti skin-aging product which may be used in the cosmetic industry |
| AAPeptide170 | NA | US 10668000 B2 | 2020 | Synthetic | NA | In vitro | Normal human fibroblasts (NHF), Human keratinocytes | Skin aging | Ameliorates the mechanical properties of skin, firming, toning, elasticity, flexibility and suppleness, Increases the density and volume of skin (volumating or re-pulping effect), Restructures skin, fights strechmarks, Improves skin barrier, and skin hydration |
| AAPeptide171 | NA | US 10799442 B2 | 2020 | Synthetic | NA | In vitro, In vivo | Human Epidermal Keratinocytes from Adult (HEKa), Human Keratinocyte (HaCaT) cell line, Reconstructed Human Epidermal Tissue (RHE) | Skin aging | Decreases miRNA expression in human keratinocytes and, as a result, increase the levels of transcription factors involved in the self-renewing processes of the skin |
| AAPeptide172 | NA | US 10660839 B2 | 2020 | Synthetic | NA | In vitro | Mouse melanoma (B16 cells), Normal human melanocytes (HEMn cells), Human keratinocytes | Skin aging | Treats the default of complexion homogeneity, the loss of collagen in the skin extracellular matrix or for stimulating the synthesis of collagen to obtain a volumizing effect, Addresses the loss of skin hydration by improving the skin barrier, Uses as anti-wrinkles and fine lines treatment |
| AAPeptide173 | NA | US 10799442 B2 | 2020 | Synthetic | NA | In vitro, Randomized clinical trial | Human Epidermal Keratinocytes from Adult (HEKa), Human Keratinocyte (HaCaT) cell line, Reconstructed Human Epidermal Tissue (RHE) | Skin aging | Decreases miRNA expression in human keratinocytes and, as a result, increase the levels of transcription factors involved in the self-renewing processes of the skin |
| AAPeptide174 | NA | US 10799442 B2 | 2020 | Synthetic | NA | In vitro, Randomized clinical trial | Human Epidermal Keratinocytes from Adult (HEKa), Human Keratinocyte (HaCaT) cell line, Reconstructed Human Epidermal Tissue (RHE) | Skin aging | Decreases miRNA expression in human keratinocytes and, as a result, increase the levels of transcription factors involved in the self-renewing processes of the skin |
| AAPeptide175 | NA | US 10799442 B2 | 2020 | Synthetic | NA | In vitro, Randomized clinical trial | Human Epidermal Keratinocytes from Adult (HEKa), Human Keratinocyte (HaCaT) cell line, Reconstructed Human Epidermal Tissue (RHE) | Skin aging | Decreases miRNA expression in human keratinocytes and, as a result, increase the levels of transcription factors involved in the self-renewing processes of the skin |
| AAPeptide176 | NA | US 10799442 B2 | 2020 | Synthetic | NA | In vitro, Randomized clinical trial | Human Epidermal Keratinocytes from Adult (HEKa), Human Keratinocyte (HaCaT) cell line, Reconstructed Human Epidermal Tissue (RHE) | Skin aging | Decreases miRNA expression in human keratinocytes and, as a result, increase the levels of transcription factors involved in the self-renewing processes of the skin |
| AAPeptide177 | NA | US 10799442 B2 | 2020 | Synthetic | NA | In vitro, Randomized clinical trial | Human Epidermal Keratinocytes from Adult (HEKa), Human Keratinocyte (HaCaT) cell line, Reconstructed Human Epidermal Tissue (RHE) | Skin aging | Decreases miRNA expression in human keratinocytes and, as a result, increase the levels of transcription factors involved in the self-renewing processes of the skin |
| AAPeptide178 | NA | US 10799442 B2 | 2020 | Synthetic | NA | In vitro, Randomized clinical trial | Human Epidermal Keratinocytes from Adult (HEKa), Human Keratinocyte (HaCaT) cell line, Reconstructed Human Epidermal Tissue (RHE) | Skin aging | Decreases miRNA expression in human keratinocytes and, as a result, increase the levels of transcription factors involved in the self-renewing processes of the skin |
| AAPeptide179 | NA | US 10799442 B2 | 2020 | Synthetic | NA | In vitro, Randomized clinical trial | Human Epidermal Keratinocytes from Adult (HEKa), Human Keratinocyte (HaCaT) cell line, Reconstructed Human Epidermal Tissue (RHE) | Skin aging | Decreases miRNA expression in human keratinocytes and, as a result, increase the levels of transcription factors involved in the self-renewing processes of the skin |
| AAPeptide180 | NA | US 10799442 B2 | 2020 | Synthetic | NA | In vitro, Randomized clinical trial | Human Epidermal Keratinocytes from Adult (HEKa), Human Keratinocyte (HaCaT) cell line, Reconstructed Human Epidermal Tissue (RHE) | Skin aging | Decreases miRNA expression in human keratinocytes and, as a result, increase the levels of transcription factors involved in the self-renewing processes of the skin |