AagingBase: Database of anti-aging peptides
A manually curated comprehensive database for anti-aging peptidesThe Literature info page of AAPeptide gives experimental informations of anti-aging peptides of AagingBase that were collected from scholarly articles and patents. Users can find the data in a filterable and sortable table. To obtain further details, refer to the Help page.
| AAP_ID | Reported name | ID | Year | Origin | Source | Experiment type | Cell lines/Animal model | Condition addressed | Bioactivity |
|---|---|---|---|---|---|---|---|---|---|
| AAPeptide081 | Tetrapeptide | US 10231917 B2 | 2019 | Natural | Human | In vitro | Human melanocytes (HEMn cells) | Skin aging | Treats cutaneous white spots, canities, the loss of collagen in skin extracellular matrix, Treats loss of skin hydration by improving the skin barrier, Treats wrinkles and fine lines, moisturizing the skin and/or unifying skin complexion |
| AAPeptide082 | L1-12 | 31081964 | 2019 | Synthetic | NA | In vitro | HepG2 cell line | Oxidative stress | Enhances the expressions of the Cat‐1 and Nhr‐8 genes to reduce oxidative damage, leading to an extension of the lifespan, Activates Nhr‐8 resulting to degrade toxic substances, Increases the expression of antioxidant enzyme genes to resist stress, therefore extend lifespan. |
| AAPeptide083 | NA | US 10463592 B2 | 2019 | Natural | Human | In vitro | Human monocytic cell line THP-1, Normal human dermal fibroblasts (newborns) | Skin aging | Promotes the fibroblast growth, hyaluronic acid production or contracting collagen gels, Prevents wrinkles or sagging of the skin or the reduction of the skin elasticity |
| AAPeptide084 | NA | US 10246446 B2 | 2019 | Natural | Mice | In vitro, In vivo | HEK293 cell line, Mice | Disorders related to GH | Attenuate/delay the growth of GH, Attenuate/delay changes in biomarkers associated with aging |
| AAPeptide085 | NA | US 2019/0134156 A2 | 2019 | Synthetic | NA | In vitro, In vivo | Human umbilical vein endothelial cells (HUVEC), Swiss Webster mice | Age related tissue damage | Protects from nerve damage and neuropathy, Activates AKT |
| AAPeptide086 | NA | US 2019/0134156 A1 | 2019 | Synthetic | NA | In vivo | Human umbilical vein endothelial cells (HUVEC), Swiss Webster mice | Age related tissue damage | Protects from nerve damage and neuropathy, Activates AKT |
| AAPeptide087 | NA | US 2019/0010191 A1 | 2019 | Synthetic | NA | In vitro | Human abdominal skin | Skin aging | Treats the signs of dry skin, skin aging, trophic skin disorders or those following disorders of healing, thinning of the epidermis and in particular of the stratum corneum and/or for treating excessive fragility of the skin |
| AAPeptide088 | Tripeptide-1 | US 11052032 B2, US 2019/0038539 A1 | 2021,2019 | Synthetic | NA | In vitro, Randomized controlled trial | Dermal fibroblasts, 3T3-L1 adipocytes | Aging associated skin laxity | Enhance skin regeneration, Promote wound healing,Improves skin laxity, texture, or crepiness or body contouring |
| AAPeptide089 | NA | US 10463591 B2 | 2019 | Natural | Rice/Pea/Mouse | In vitro | I_1_HR (Rice), E_1_HR (Pea), J774.2 mouse macrophage cell line | Skin aging | Skin lightening, Skin healing |
| AAPeptide090 | 5-HAYED | 30448512 | 2019 | Synthetic | NA | In vitro, In vivo | Neuroblastoma cell line SH-sy5y, Mice | Brain aging | Have higher affinity to iron than Aβ42, Protects cells by reducing radicals in vitro, Prevents brain injury from radicals, Ameliorates cognitive impairment in the senescence mice |
| AAPeptide091 | RTE62G (pep_RTE62G) | US 10925922 B2, EP 3590523 A1, US 2019/0321436 A1, 32453870 | 2021,2020,2019 | Natural | Pisum sativum | In vitro, Randomized clinical trial | Human Dermal Fibroblasts (HDF—Sigma 10605a), Immortalised human keratinocytes (HaCaT) | Skin aging | Treats diseases or conditions characterised by damaged epithelial cells or tissue such as colon cancer and peripheral inflammatory disorders, and wound treatment, Prevents skin aging, Stimulates key dermal proteins, implicated in skin aging, namely collagen, elastin and fibrillin |
| AAPeptide092 | NA | US 10195245 B2 | 2019 | Synthetic | NA | In vitro | Human skin keratinocytes (ATCC CRL-2404), SOR-300-FT Human Psoriasis Tissue Construct | Wound from aging | Stimulatory activities towards cell migration and effect wound repair |
| AAPeptide093 | NA | US 10195245 B2 | 2019 | Synthetic | NA | In vitro | Human skin keratinocytes (ATCC CRL-2404) , SOR-300-FT Human Psoriasis Tissue Construct | Wound from aging | Stimulatory activities towards cell migration and effect wound repair |
| AAPeptide094 | NA | US 2019/0153045 A1 | 2019 | Natural | Oryza sativa | In vitro, Ex vivo | Skin fibroblasts derived healthy Caucasian females of different ages, Adult dermal fibroblasts, Human skin explants | Skin aging | Increases production of elastic fibers |
| AAPeptide095 | NA | US 2019/0153045 A1, US 10844101 B2 | 2020,2019 | Natural | Oryza sativa | In vitro, Ex vivo | Skin fibroblasts derived healthy Caucasian females of different ages, Adult dermal fibroblasts, Human skin explants | Skin aging | Increases production of elastic fibers |
| AAPeptide096 | NA | US 2019/0153045 A1 | 2019 | Natural | Oryza sativa | In vitro, Ex vivo | Skin fibroblasts derived healthy Caucasian females of different ages, Adult dermal fibroblasts, Human skin explants | Skin aging | Increases production of elastic fibers |
| AAPeptide097 | NA | US 2019/0153045 A1, US 10844101 B2 | 2020,2019 | Natural | Oryza sativa | In vitro, Ex vivo | Skin fibroblasts derived healthy Caucasian females of different ages, Adult dermal fibroblasts, Human skin explants | Skin aging | Increases production of elastic fibers |
| AAPeptide098 | NA | US 10167325 B2 | 2019 | Natural | Oryza sativa | In vitro, Ex vivo | Skin fibroblasts derived healthy Caucasian females of different ages, Adult dermal fibroblasts, Human skin explants | Skin aging | Increases elastogenesis in tissue, Stimulates proliferation and migration of dermal fibroblasts into an area of skin |
| AAPeptide099 | NA | US 2019/0153045 A1 | 2019 | Natural | Oryza sativa | In vitro, Ex vivo | Skin fibroblasts derived healthy Caucasian females of different ages, Adult dermal fibroblasts, Human skin explants | Skin aging | Increases production of elastic fibers |
| AAPeptide100 | NA | US 2019/0153045 A1 | 2019 | Natural | Oryza sativa | In vitro, Ex vivo | Skin fibroblasts derived healthy Caucasian females of different ages, Adult dermal fibroblasts, Human skin explants | Skin aging | Increases production of elastic fibers |