AagingBase | Database of anti-aging peptide

AagingBase: Database of anti-aging peptides A manually curated comprehensive database for anti-aging peptides

Peptide Card for AAPeptide090

The Peptide Card page for AAPeptide090 gives textual and graphical visualizations of the properties of AAPeptide090. The users can find all the literature informations collected from scholarly articles and patents and the calculated physicochemical informations. There are also graphical representations hydropathy values, amino acid compositions and frequencies, atomic compositions and secondary structure fractions of AAPeptide090.
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AAP ID	AAPeptide090
Peptide name	5-HAYED
PubMed/Patent ID	30448512
Origin	Synthetic
Source of Origin	NA
Condition addressed	Brain aging
Experiment type	In vitro, In vivo
Cell lines/Animal model	Neuroblastoma cell line SH-sy5y, Mice
Intervention	Cells were treated with the peptide
Experiment methods	In vitro hydroxyl radical reducing effect assay, In vitro cell viability assay, Hydroxyl radical measurement, Iron content measurement, Morris water maze (MWM) test, Passive avoidance test (PAT), Functional magnetic resonance imaging (fMRI) Assay on the oxygen metabolism level of mice brain, Blood biochemical Analysis, TUNNEL Assay
Patient group	NA
Markers used	NA
Mechanism of action	Have higher affinity to iron than Aβ42, Protects cells by reducing radicals in vitro, Prevents brain injury from radicals, Ameliorates cognitive impairment in the senescence mice

Molecular weight	3095.974
Peptide length	25
Instability index	33.040
Aromaticity	0.200
Aliphaticity	0.200
Reduced molecular extinction coeffecient	7450
Oxidized molecular extinction coeffecient	7450
Isoelectric point	4.343
Composition of positively charged residues	0.200
Composition of negatively charged residues	0.400
Composition of neutral charged residues	0.400
Composition of residues polar residues	0.200
Composition of residues non-polar residues	0.200
Composition of residues having cyclic side chain	0.000
Composition of acidic residues	0.400
Composition of basic residues	0.200
Composition of residues having cyclic side chain	0.000
Composition of hydroxylic residues	0.000
Composition of residue in buried solvent accessibility	0.200
Composition of residue in exposed solvent accessibility	0.400
Composition of residue in intermediate solvent accessibility	0.400

AAPeptide090 :

HAYEDHAYEDHAYEDHAYEDHAYED

Amino acid data

ProtScale

Atomic information

3D Structure

Structural Representation of AAPeptide090

Amino acid data

Secondary structure fraction