AagingBase: Database of anti-aging peptides
A manually curated comprehensive database for anti-aging peptidesThe Literature info page of AAPeptide gives experimental informations of anti-aging peptides of AagingBase that were collected from scholarly articles and patents. Users can find the data in a filterable and sortable table. To obtain further details, refer to the Help page.
| AAP_ID | Reported name | ID | Year | Origin | Source | Experiment type | Cell lines/Animal model | Condition addressed | Bioactivity |
|---|---|---|---|---|---|---|---|---|---|
| AAPeptide181 | NA | US 10799442 B2 | 2020 | Synthetic | NA | In vitro, Randomized clinical trial | Human Epidermal Keratinocytes from Adult (HEKa), Human Keratinocyte (HaCaT) cell line, Reconstructed Human Epidermal Tissue (RHE) | Skin aging | Decreases miRNA expression in human keratinocytes and, as a result, increase the levels of transcription factors involved in the self-renewing processes of the skin |
| AAPeptide182 | NA | US 10799442 B2 | 2020 | Synthetic | NA | In vitro, Randomized clinical trial | Human Epidermal Keratinocytes from Adult (HEKa), Human Keratinocyte (HaCaT) cell line, Reconstructed Human Epidermal Tissue (RHE) | Skin aging | Decreases miRNA expression in human keratinocytes and, as a result, increase the levels of transcription factors involved in the self-renewing processes of the skin |
| AAPeptide183 | NA | US 10799442 B2 | 2020 | Synthetic | NA | In vitro, Randomized clinical trial | Human Epidermal Keratinocytes from Adult (HEKa), Human Keratinocyte (HaCaT) cell line, Reconstructed Human Epidermal Tissue (RHE) | Skin aging | Decreases miRNA expression in human keratinocytes and, as a result, increase the levels of transcription factors involved in the self-renewing processes of the skin |
| AAPeptide184 | NA | US 10799442 B2 | 2020 | Synthetic | NA | In vitro, Randomized clinical trial | Human Epidermal Keratinocytes from Adult (HEKa), Human Keratinocyte (HaCaT) cell line, Reconstructed Human Epidermal Tissue (RHE) | Skin aging | Decreases miRNA expression in human keratinocytes and, as a result, increase the levels of transcription factors involved in the self-renewing processes of the skin |
| AAPeptide185 | NA | US 10799442 B2 | 2020 | Synthetic | NA | In vitro, Randomized clinical trial | Human Epidermal Keratinocytes from Adult (HEKa), Human Keratinocyte (HaCaT) cell line, Reconstructed Human Epidermal Tissue (RHE) | Skin aging | Decreases miRNA expression in human keratinocytes and, as a result, increase the levels of transcription factors involved in the self-renewing processes of the skin |
| AAPeptide186 | NA | US 10799442 B2 | 2020 | Synthetic | NA | In vitro, Randomized clinical trial | Human Epidermal Keratinocytes from Adult (HEKa), Human Keratinocyte (HaCaT) cell line, Reconstructed Human Epidermal Tissue (RHE) | Skin aging | Decreases miRNA expression in human keratinocytes and, as a result, increase the levels of transcription factors involved in the self-renewing processes of the skin |
| AAPeptide187 | S1200 | US 10800824 B2 | 2020 | Natural | Human | In vitro | Human foreskin fibroblast | Skin aging | Improves skin flexibility, wrinkles and elasticity |
| AAPeptide188 | ABp-RQR | 33200472 | 2020 | Natural | NA | In vitro | NIH/3T3 cells | D-Galactose induced aging, Anti aging componet of functional food | Improves the D-gal-induced aging and enhance the activity of Nrf2 in mice, May provide alternative raw materials for anti-aging drugs and dietary supplements |
| AAPeptide189 | WINT peptide | US 2020/0289526 A1 | 2020 | Synthetic | NA | In vitro | HaCaT keratinocytes, Human Hair Dermal Papilla Cells (HHDP Cells) | Skin aging | Has excellent physiological activities such as preventing hair loss, promoting hair growth, promoting cell growth, etc, but also has excellent stability in water and skin permeability |
| AAPeptide190 | NA | US 10799442 B2 | 2020 | Synthetic | NA | In vitro, Randomized clinical trial | Human Epidermal Keratinocytes from Adult (HEKa), Human Keratinocyte (HaCaT) cell line, Reconstructed Human Epidermal Tissue (RHE) | Skin aging | Decreases miRNA expression in human keratinocytes and, as a result, increase the levels of transcription factors involved in the self-renewing processes of the skin |
| AAPeptide191 | RGD motif-containing peptide or a fragment | US 10632181 B2 | 2020 | Natural | Human | In vivo, Randomized clinical trial | SD (Sprague-Dawley) rats | Skin aging | Effectively treat burns and glaucoma, obtain an excellent effect of alleviating skin wrinkles, and is effective in the promotion of hair restoration and hair growth as well as the prevention of hair loss |
| AAPeptide192 | Intermedin | 32229709 | 2020 | Natural | Human | In vitro | Rat vascular smooth muscle cells (VSMCs), Human VSMC CRL1999 cells, Sprague-Dawley (SD) rats | Vascular calcification | Has a protective role in aging-associated vascular calcification |
| AAPeptide193 | H-PROT-1 | 32365755 | 2020 | Natural | Ulva intestinalis | In vitro | Human dermal fibroblasts | Skin aging | Promotes in vitro collagen and hyaluronic acid biosynthesis by dermal fibroblasts without activating cell proliferation |
| AAPeptide194 | Acetylcholine receptor-binding peptide | US 2020/0123199 A1 | 2020 | Synthetic | NA | NA | NA | Skin aging | Peptides according to the present disclosure suppress secretion of acetylcholine by having a high binding strength with an acetylcholine receptor, thereby strongly binding the peptides to acetylcholine Therefore, a cosmetic composition and a pharmaceutical composition comprising peptides according to the present disclosure as an active ingredient exhibit an excellent wrinkle ameliorating effect |
| AAPeptide195 | NA | US 10729636 B2 | 2020 | Synthetic | NA | In vitro, In vivo | Human Dermal Fibroblasts (HDF), Human keratinocytes, Human Skeletal Muscle Cells (HSkMC), KK.Cg-Ay/J (KKAY mouse) | Skin aging | Improves fine lines, wrinkles, dryness reducing redness and irritation |
| AAPeptide196 | Acetylcholine receptor-binding peptide | US 2020/0123199 A1 | 2020 | Synthetic | NA | NA | NA | Skin aging | Suppress secretion of acetylcholine, Exhibits an excellent wrinkle ameliorating effect |
| AAPeptide197 | Acetylcholine receptor-binding peptide | US 2020/0123199 A1 | 2020 | Synthetic | NA | NA | NA | Skin aging | Suppress secretion of acetylcholine, Exhibits an excellent wrinkle ameliorating effect |
| AAPeptide198 | Acetylcholine receptor-binding peptide | US 2020/0123199 A1 | 2020 | Synthetic | NA | NA | NA | Skin aging | Suppress secretion of acetylcholine, Exhibits an excellent wrinkle ameliorating effect |
| AAPeptide199 | Acetylcholine receptor-binding peptide | US 2020/0123199 A1 | 2020 | Synthetic | NA | NA | NA | Skin aging | Suppress secretion of acetylcholine, Exhibits an excellent wrinkle ameliorating effect |
| AAPeptide200 | Acetylcholine receptor-binding peptide | US 2020/0123199 A1 | 2020 | Synthetic | NA | NA | NA | Skin aging | Suppress secretion of acetylcholine, Exhibits an excellent wrinkle ameliorating effect |