AagingBase | Database of anti-aging peptide

AagingBase: Database of anti-aging peptides A manually curated comprehensive database for anti-aging peptides

Peptide Card for AAPeptide186

The Peptide Card page for AAPeptide186 gives textual and graphical visualizations of the properties of AAPeptide186. The users can find all the literature informations collected from scholarly articles and patents and the calculated physicochemical informations. There are also graphical representations hydropathy values, amino acid compositions and frequencies, atomic compositions and secondary structure fractions of AAPeptide186.
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AAP ID	AAPeptide186
Peptide name	NA
PubMed/Patent ID	US 10799442 B2
Origin	Synthetic
Source of Origin	NA
Condition addressed	Skin aging
Experiment type	In vitro, Randomized clinical trial
Cell lines/Animal model	Human Epidermal Keratinocytes from Adult (HEKa), Human Keratinocyte (HaCaT) cell line, Reconstructed Human Epidermal Tissue (RHE)
Intervention	Cells were treated with the peptide, Topical application of the formulation
Experiment methods	qRT-PCR, miRNA145 quantification assay based on luminescence detection, Immunohistochemistry, Stratum corneum turnover time (SCTT) assessment, Skin roughness assessment , Luminosity of the skin (parameter L*) or skin radiance measurement in macrophotographies using cross-polarized filters
Patient group	63 Caucasian female volunteers (20 aged between 18 and 25 years old—group I, 20 aged between 35 and 40 years old—group II, and 20 aged between 50 and 55 years old—group III)
Markers used	SOX2, OCT4, KLF4 and MYC (Stem cell markers), p63 (keratinocyte stem cell marker)
Mechanism of action	Decreases miRNA expression in human keratinocytes and, as a result, increase the levels of transcription factors involved in the self-renewing processes of the skin

Molecular weight	820.981
Peptide length	6
Instability index	15.300
Aromaticity	0.000
Aliphaticity	0.000
Reduced molecular extinction coeffecient	0
Oxidized molecular extinction coeffecient	0
Isoelectric point	9.750
Composition of positively charged residues	0.167
Composition of negatively charged residues	0.000
Composition of neutral charged residues	0.833
Composition of residues polar residues	0.500
Composition of residues non-polar residues	0.333
Composition of residues having cyclic side chain	0.000
Composition of acidic residues	0.000
Composition of basic residues	0.167
Composition of residues having cyclic side chain	0.000
Composition of hydroxylic residues	0.000
Composition of residue in buried solvent accessibility	0.000
Composition of residue in exposed solvent accessibility	0.500
Composition of residue in intermediate solvent accessibility	0.333

AAPeptide186 :

QQMRMQ

Amino acid data

ProtScale

Disclaimer: Hydropathy plot is not available for AAPeptide186 as the peptide length is less than 9 amino acid residues

Atomic information

3D Structure

Structural Representation of AAPeptide186

Amino acid data

Secondary structure fraction