AagingBase | Database of anti-aging peptide

Peptide Card for AAPeptide186


The Peptide Card page for AAPeptide186 gives textual and graphical visualizations of the properties of AAPeptide186. The users can find all the literature informations collected from scholarly articles and patents and the calculated physicochemical informations. There are also graphical representations hydropathy values, amino acid compositions and frequencies, atomic compositions and secondary structure fractions of AAPeptide186.
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AAP IDAAPeptide186
Peptide nameNA
PubMed/Patent IDUS 10799442 B2
OriginSynthetic
Source of OriginNA
Condition addressedSkin aging
Experiment typeIn vitro, Randomized clinical trial
Cell lines/Animal modelHuman Epidermal Keratinocytes from Adult (HEKa), Human Keratinocyte (HaCaT) cell line, Reconstructed Human Epidermal Tissue (RHE)
InterventionCells were treated with the peptide, Topical application of the formulation
Experiment methodsqRT-PCR, miRNA145 quantification assay based on luminescence detection, Immunohistochemistry, Stratum corneum turnover time (SCTT) assessment, Skin roughness assessment , Luminosity of the skin (parameter L*) or skin radiance measurement in macrophotographies using cross-polarized filters
Patient group63 Caucasian female volunteers (20 aged between 18 and 25 years old—group I, 20 aged between 35 and 40 years old—group II, and 20 aged between 50 and 55 years old—group III)
Markers usedSOX2, OCT4, KLF4 and MYC (Stem cell markers), p63 (keratinocyte stem cell marker)
Mechanism of actionDecreases miRNA expression in human keratinocytes and, as a result, increase the levels of transcription factors involved in the self-renewing processes of the skin
Molecular weight820.981
Peptide length6
Instability index15.300
Aromaticity0.000
Aliphaticity0.000
Reduced molecular extinction coeffecient0
Oxidized molecular extinction coeffecient0
Isoelectric point9.750
Composition of positively charged residues0.167
Composition of negatively charged residues0.000
Composition of neutral charged residues0.833
Composition of residues polar residues0.500
Composition of residues non-polar residues0.333
Composition of residues having cyclic side chain0.000
Composition of acidic residues0.000
Composition of basic residues0.167
Composition of residues having cyclic side chain0.000
Composition of hydroxylic residues0.000
Composition of residue in buried solvent accessibility0.000
Composition of residue in exposed solvent accessibility0.500
Composition of residue in intermediate solvent accessibility0.333

AAPeptide186 :
QQMRMQ

Amino acid data
ProtScale


Disclaimer: Hydropathy plot is not available for AAPeptide186 as the peptide length is less than 9 amino acid residues

Atomic information


3D Structure

Structural Representation of AAPeptide186

Amino acid data
Secondary structure fraction