AagingBase: Database of anti-aging peptides
A manually curated comprehensive database for anti-aging peptidesThe Literature info page of AAPeptide gives experimental informations of anti-aging peptides of AagingBase that were collected from scholarly articles and patents. Users can find the data in a filterable and sortable table. To obtain further details, refer to the Help page.
| AAP_ID | Reported name | ID | Year | Origin | Source | Experiment type | Cell lines/Animal model | Condition addressed | Bioactivity |
|---|---|---|---|---|---|---|---|---|---|
| AAPeptide061 | GDF11 and TGFβ peptide fragment | US 9999649 B2 | 2018 | Natural | Human | In vitro | Human dermal fibroblast cells | Skin aging | Increase in pro-collagen 1 production |
| AAPeptide062 | MyD88 inhibitor | EP 3366302 A1 | 2018 | Synthetic | NA | In vitro, In vivo, Ex vivo | Primary mouse RPE cells, HeLa cells, THP-1 cells, C57BL/6J mice | Age-related macular degeneration | Cell protection |
| AAPeptide063 | MyD88 inhibitor | EP 3366302 A1 | 2018 | Synthetic | NA | In vitro, In vivo, Ex vivo | Primary mouse RPE cells, HeLa cells, THP-1 cells, Wild-type C57BL/6J mice | Age-related macular degeneration | Cell protection |
| AAPeptide064 | NA | US 9932368 B2 | 2018 | Natural | Human | In vitro, Ex vivo | Human dermal fibroblasts, HeLa (CCL-2), Human dermal papilla, Normal Hs68 (CRL-1635) | Skin aging | Anti-wrinkle, Skin stimulating, Skin repairing |
| AAPeptide065 | NA | US 9932368 B2 | 2018 | Natural | Human | In vitro, Ex vivo | Human dermal fibroblasts, HeLa (CCL-2), Human dermal papilla, normal Hs68 (CRL-1635) | Skin aging | Anti-wrinkle, Skin stimulating, Skin repairing |
| AAPeptide066 | NA | US 10086039 B2 | 2018 | Natural | Human | In vitro | Human dermal fibroblasts, HEK293 cells, MEFs | Aging-related degenerative diseases | Aging-related degenerative diseases |
| AAPeptide067 | ACT1 peptide | US 9855313 B2 | 2018 | Synthetic | NA | In vitro | Myocytes from neonatal rat hearts, WB-F344 cells (rat epithelial cell line) | Skin aging | Promotes healing, regeneration |
| AAPeptide068 | ACT3 peptide | US 9855313 B2 | 2018 | Synthetic | NA | In vitro | Myocytes from neonatal rat hearts, WB-F344 cells (rat epithelial cell line) | Skin aging | Promotes healing, regeneration |
| AAPeptide069 | ACT4 peptide | US 9855313 B2 | 2018 | Synthetic | NA | In vitro | Myocytes from neonatal rat hearts, WB-F344 cells (rat epithelial cell line) | Skin aging | Promotes healing, regeneration |
| AAPeptide070 | CTGF peptide fragment | US 9999649 B2 | 2018 | Natural | Human | In vitro | Human dermal fibroblast cells | Skin aging | Increase in hyaluronic acid production |
| AAPeptide071 | Phycobiliproteins (PBPs) | 29717771 | 2018 | Natural | Porphyra purpurea | In vitro | HepG2 human hepatoblastoma cell line | Cell aging | Upregulates the protein expression of p-Nrf2 and antioxidant enzymes, Attenuates H2O2-induced oxidative stress in the cells |
| AAPeptide072 | Metallothioneins (MT) peptide fragments | US 10100100 B2 | 2018 | Natural | NA | In vitro | Primary CGN cultures | Aging-related degenerative diseases | Stimulates neuronal cell differentiation, neuronal cell survival and neural plasticity associated with learning and memory, Inhibites the oxidative stress and inflammatory responses, Modulates survival and neuroprotection, Promotes the effects of growth factors and regulatory molecules and their receptors |
| AAPeptide073 | Angiogenic peptide | US 9925398 B2 | 2018 | Synthetic | NA | In vitro | MS-1 cells and B16F1 murine melanoma cells, Human umbilical vein endothelial cells (HUVECs) | Skin aging | Anti-wrinkle and enhances skin whitening |
| AAPeptide074 | 2n7-1 | US 10945940 B2, US 2018/0344608 A1 | 2021,2018 | Natural | Chicken, Bird or mammal | In vitro | Human dermal fibroblasts | Skin aging | Improves skin aging or skin wrinkles |
| AAPeptide075 | SKIP | US 10118943 B2 | 2018 | Synthetic | NA | In vitro, In vivo | Rat pheochromocytoma cell (PC12), ADNP heterozygous mice | Cell death | Promotes cell survival and/or plasticity, especially in neuronal cells, by targeting the microtubule End Binding (EB) proteins and other associated proteins (eg , drebrin) |
| AAPeptide076 | CTGF peptide fragment | US 9999649 B2 | 2018 | Natural | Human | In vitro | Human dermal fibroblast cells | Skin aging | Increase in pro-collagen 1 and hyaluronic acid production |
| AAPeptide077 | Low-molecular-weight protamine (LMWP)-fused bFGF (LMWP-bFGF) | 29448503 | 2018 | Natural | NA | In vitro | Human keratinocyte (HaCaT), Human fibroblast (CCD-986sk) | Skin aging | Effective topical therapeutic or cosmeceutic agents for skin regeneration |
| AAPeptide078 | NA | US 9932368 B2 | 2018 | Natural | Human | In vitro, Ex vivo | Human dermal fibroblasts, HeLa (CCL-2), Human dermal papilla, Normal Hs68 (CRL-1635) | Skin aging | Anti-wrinkle effect, Skin stimulating, Skin repairing |
| AAPeptide079 | NA | US 9999649 B2 | 2018 | Natural | Human | In vitro | Human skin fibroblasts (Hs27) | Skin aging | Treats wrinkles and repairs wounds |
| AAPeptide080 | Tetrapeptide | US 10231917 B2 | 2019 | Natural | Human | In vitro | Human melanocytes (HEMn cells) | Skin aging | Treats cutaneous white spots, canities, the loss of collagen in skin extracellular matrix, Treats loss of skin hydration by improving the skin barrier, Treats wrinkles and fine lines, moisturizing the skin and/or unifying skin complexion |