AagingBase | Database of anti-aging peptide

AagingBase: Database of anti-aging peptides A manually curated comprehensive database for anti-aging peptides

Peptide Card for AAPeptide075

The Peptide Card page for AAPeptide075 gives textual and graphical visualizations of the properties of AAPeptide075. The users can find all the literature informations collected from scholarly articles and patents and the calculated physicochemical informations. There are also graphical representations hydropathy values, amino acid compositions and frequencies, atomic compositions and secondary structure fractions of AAPeptide075.
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AAP ID	AAPeptide075
Peptide name	SKIP
PubMed/Patent ID	US 10118943 B2
Origin	Synthetic
Source of Origin	NA
Condition addressed	Cell death
Experiment type	In vitro, In vivo
Cell lines/Animal model	Rat pheochromocytoma cell (PC12), ADNP heterozygous mice
Intervention	Cells were treated with the peptide after zinc intoxification, Intranasal administration of the peptide
Experiment methods	ELISA, MTS cell viability and cytotoxicity assay, Object Recognition Test, Morris Water Maze (MWM), Elevated Plus-Maze
Patient group	NA
Markers used	NA
Mechanism of action	Promotes cell survival and/or plasticity, especially in neuronal cells, by targeting the microtubule End Binding (EB) proteins and other associated proteins (eg , drebrin)

Molecular weight	443.538
Peptide length	4
Instability index	-20.925
Aromaticity	0.000
Aliphaticity	0.500
Reduced molecular extinction coeffecient	0
Oxidized molecular extinction coeffecient	0
Isoelectric point	8.465
Composition of positively charged residues	0.250
Composition of negatively charged residues	0.000
Composition of neutral charged residues	0.750
Composition of residues polar residues	0.250
Composition of residues non-polar residues	0.500
Composition of residues having cyclic side chain	0.250
Composition of acidic residues	0.000
Composition of basic residues	0.250
Composition of residues having cyclic side chain	0.250
Composition of hydroxylic residues	0.250
Composition of residue in buried solvent accessibility	0.250
Composition of residue in exposed solvent accessibility	0.500
Composition of residue in intermediate solvent accessibility	0.500

AAPeptide075 :

SKIP

Amino acid data

ProtScale

Disclaimer: Hydropathy plot is not available for AAPeptide075 as the peptide length is less than 9 amino acid residues

Atomic information

3D Structure

Structural Representation of AAPeptide075

Amino acid data

Secondary structure fraction