AagingBase | Database of anti-aging peptide

AagingBase: Database of anti-aging peptides A manually curated comprehensive database for anti-aging peptides

Peptide Card for AAPeptide062

The Peptide Card page for AAPeptide062 gives textual and graphical visualizations of the properties of AAPeptide062. The users can find all the literature informations collected from scholarly articles and patents and the calculated physicochemical informations. There are also graphical representations hydropathy values, amino acid compositions and frequencies, atomic compositions and secondary structure fractions of AAPeptide062.
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AAP ID	AAPeptide062
Peptide name	MyD88 inhibitor
PubMed/Patent ID	EP 3366302 A1
Origin	Synthetic
Source of Origin	NA
Condition addressed	Age-related macular degeneration
Experiment type	In vitro, In vivo, Ex vivo
Cell lines/Animal model	Primary mouse RPE cells, HeLa cells, THP-1 cells, C57BL/6J mice
Intervention	Cells were transfected with plasmid containing peptide siRNA sense, Subretinal injections of the peptide in mice
Experiment methods	Immunostaining, Western blot, MTS Cell viability and cytotoxicity assay, H2DCF DA ROS assay, RNA-binding protein immunoprecipitation (RIP), ELISA , Caspase-8 activity assessment
Patient group	Donor eyes or ocular tissues from patients with geographic atrophy due to AMD or age-matched patients without AMD
Markers used	NA
Mechanism of action	Cell protection

Molecular weight	756.847
Peptide length	7
Instability index	23.957
Aromaticity	0.000
Aliphaticity	0.571
Reduced molecular extinction coeffecient	0
Oxidized molecular extinction coeffecient	0
Isoelectric point	5.836
Composition of positively charged residues	0.143
Composition of negatively charged residues	0.143
Composition of neutral charged residues	0.714
Composition of residues polar residues	0.143
Composition of residues non-polar residues	0.571
Composition of residues having cyclic side chain	0.143
Composition of acidic residues	0.143
Composition of basic residues	0.143
Composition of residues having cyclic side chain	0.143
Composition of hydroxylic residues	0.143
Composition of residue in buried solvent accessibility	0.429
Composition of residue in exposed solvent accessibility	0.286
Composition of residue in intermediate solvent accessibility	0.286

AAPeptide062 :

RDVLPGT

Amino acid data

ProtScale

Disclaimer: Hydropathy plot is not available for AAPeptide062 as the peptide length is less than 9 amino acid residues

Atomic information

3D Structure

Structural Representation of AAPeptide062

Amino acid data

Secondary structure fraction