AagingBase: Database of anti-aging peptides
A manually curated comprehensive database for anti-aging peptidesThe Literature info page of AAPeptide gives experimental informations of anti-aging peptides of AagingBase that were collected from scholarly articles and patents. Users can find the data in a filterable and sortable table. To obtain further details, refer to the Help page.
| AAP_ID | Reported name | ID | Year | Origin | Source | Experiment type | Cell lines/Animal model | Condition addressed | Bioactivity |
|---|---|---|---|---|---|---|---|---|---|
| AAPeptide121 | NA | US 2019/0010191 A1 | 2019 | Synthetic | NA | In vitro | Human abdominal skin | Skin aging | Treates the signs of dry skin, skin aging, trophic skin disorders or those following disorders of healing, thinning of the epidermis and in particular of the stratum corneum and/or for treating excessive fragility of the skin |
| AAPeptide122 | NA | US 2019/0010191 A1 | 2019 | Synthetic | NA | In vitro | Human abdominal skin | Skin aging | Treates the signs of dry skin, skin aging, trophic skin disorders or those following disorders of healing, thinning of the epidermis and in particular of the stratum corneum and/or for treating excessive fragility of the skin |
| AAPeptide123 | NA | US 2019/0010191 A1 | 2019 | Synthetic | NA | In vitro | Human abdominal skin | Skin aging | Treates the signs of dry skin, skin aging, trophic skin disorders or those following disorders of healing, thinning of the epidermis and in particular of the stratum corneum and/or for treating excessive fragility of the skin |
| AAPeptide124 | Tetrapeptide | US 2020/0022890 A1, US 10376557 B2, US 10463585 B2 | 2020,2019 | Natural | Human | In vitro | Human cadaver skin, Human dermal fibroblast, Human skin epithelial cells (CRL-2592) | Skin aging | Reduces the appearance of age spots, Improves skin tone unevenness, Wound healing, Repaires damaged skin, Maintains healthy skin, Treats skin pigmentation by interfering with the keratinocyte to melanocyte signaling processes |
| AAPeptide125 | NA | US 2019/0010191 A1 | 2019 | Synthetic | NA | In vitro | Human abdominal skin | Skin aging | Treates the signs of dry skin, skin aging, trophic skin disorders or those following disorders of healing, thinning of the epidermis and in particular of the stratum corneum and/or for treating excessive fragility of the skin |
| AAPeptide126 | Tetrapeptide, | US 2020/0022890 A1, US 10463585 B2 | 2020,2019 | Natural | Human | In vitro | Human cadaver skin | Skin aging | Treat or reduce appearance of age spots , Improve skin tone evenness,treatment of skin pigmentation by interfering with the keratinocyte to melanocyte signaling processes |
| AAPeptide127 | NA | US 2019/0142723 A1, US 10660839 B2 | 2020,2019 | Natural | Human and mouse | In vitro | Human melanocytes (HEMn cells) , Mouse melanoma (B16 cells), Human fibroblasts,Mouse melanoma (B16 cells), Normal human melanocytes (HEMn cells), Human keratinocytes | Skin aging | Treates spots, wrinkles, and fine lines, the default of complexion homogeneity, Stimulates the synthesis of collagen to obtain a volumizing effect, the loss of skin hydration by improving the skin barrier |
| AAPeptide128 | NA | US 2019/0142723 A1, US 10660839 B2 | 2020,2019 | Natural | Human and mouse | In vitro | Human melanocytes (HEMn cells) , Mouse melanoma (B16 cells), Human fibroblasts,Mouse melanoma (B16 cells), Normal human melanocytes (HEMn cells), Human keratinocytes | Skin aging | Treates spots, wrinkles, and fine lines, the default of complexion homogeneity, Stimulates the synthesis of collagen to obtain a volumizing effect, the loss of skin hydration by improving the skin barrier |
| AAPeptide129 | Annexin A1 biomimetic short peptide (ANXA1sp) | US 10172915 B2 | 2019 | Natural | Rat | In vitro, In vivo | Adult Rat Ventricular Cardiomyocytes (ARVCs), Male Sprague-Dawley (SD) | Aging-related diseases | Improves mitochondrial fnctions |
| AAPeptide130 | EPO-peptide variant | US 11197812 B2, US 2019/0254948 A1 | 2021,2019 | Natural | Human | Randomized clinical trial | NA | Skin aging | Cosmetic treatment of intact skin, including skin repair, rejuvenation of skin, natural skin glow, reduction of wrinkles, anti-aging of skin, and avoidance and improvement of dry and ruptured skin |
| AAPeptide131 | EPO-peptide variant | US 11197812 B2, US 2019/0254948 A1 | 2021,2019 | Natural | Human | Randomized clinical trial | NA | Skin aging | Cosmetic treatment of intact skin, including skin repair, rejuvenation of skin, natural skin glow, reduction of wrinkles, anti-aging of skin, and avoidance and improvement of dry and ruptured skin |
| AAPeptide132 | NA | US 2019/0142723 A1, US 10660839 B2 | 2020,2019 | Natural | Human and mouse | In vitro | Human melanocytes (HEMn cells), Mouse melanoma (B16 cells), Human fibroblasts, Human keratinocytes | Skin aging | Treats spots, wrinkles and fine lines, Teats the default of complexion homogeneity, Stimulates the synthesis of collagen to obtain a volumizing effect, Addresses the loss of skin hydration by improving the skin |
| AAPeptide133 | HU024 | US 10463720 B2 | 2019 | Synthetic | NA | Randomized clinical trial | NA | Skin aging | Treats burns and glaucoma, obtain an excellent effect in reducing skin wrinkles, and it is effective in the promotion of hair restoration and hair growth as well as the prevention of hair loss |
| AAPeptide134 | NA | US 10463591 B2 | 2019 | Natural | Rice/Pea/Mouse | In vitro | I_1_HR (Rice), E_1_HR (Pea), J774.2 mouse macrophage cell line | Skin aging | Has skin lightening, and skin healing effects |
| AAPeptide135 | NA | US 2019/0142723 A1, US 10660839 B2 | 2020,2019 | Natural | Human and mouse | In vitro | Human melanocytes (HEMn cells), Mouse melanoma (B16 cells), Human fibroblasts, Human keratinocytes | Skin aging | Treats spots, wrinkles and fine lines, Teats the default of complexion homogeneity, Stimulates the synthesis of collagen to obtain a volumizing effect, Addresses the loss of skin hydration by improving the skin |
| AAPeptide136 | NA | US 2019/0142723 A1, US 10660839 B2 | 2020,2019 | Natural | Human and mouse | In vitro | Human melanocytes (HEMn cells) , Mouse melanoma (B16 cells), Human fibroblasts,Mouse melanoma (B16 cells), Normal human melanocytes (HEMn cells), Human keratinocytes | Skin aging | Treats spots, wrinkles and fine lines, Teats the default of complexion homogeneity, Stimulates the synthesis of collagen to obtain a volumizing effect, Addresses the loss of skin hydration by improving the skin |
| AAPeptide137 | NA | US 10246446 B2 | 2019 | Natural | Mice | In vitro, In vivo | HEK293 cell line, Mice | Skin aging | Attenuates the growth of GH, Attenuates changes in biomarkers associated with aging |
| AAPeptide138 | NA | US 2019/0343923 A1, US 10314888 B2 | 2019 | Natural | Human | In vitro | Human Mesenchymal Stem Cells (Fibrocytes), Dog Pancreas (NAT-CRT) | Skin aging | Reduces wrinkles and/or fine lines, Tissue repair and reconstruction, Treats a wound in a patient suffering from delayed wound healing |
| AAPeptide139 | NA | US 10246446 B2 | 2019 | Natural | Mice | In vitro, In vivo | HEK293 cell line, Mice | Skin aging | Attenuates the growth of GH, Attenuates changes in biomarkers associated with aging |
| AAPeptide140 | NA | US 10195245 B2 | 2019 | Synthetic | NA | In vitro | Human skin keratinocytes (ATCC CRL-2404), SOR-300-FT Human Psoriasis Tissue Construct | Wound from aging | Stimulatory activities towards cell migration and effect wound repair |