AagingBase: Database of anti-aging peptides
A manually curated comprehensive database for anti-aging peptidesThe Literature info page of AAPeptide gives experimental informations of anti-aging peptides of AagingBase that were collected from scholarly articles and patents. Users can find the data in a filterable and sortable table. To obtain further details, refer to the Help page.
| AAP_ID | Reported name | ID | Year | Origin | Source | Experiment type | Cell lines/Animal model | Condition addressed | Bioactivity |
|---|---|---|---|---|---|---|---|---|---|
| AAPeptide041 | 2n7-5 | US 10945940 B2, US 2018/0344608 A1 | 2021,2018 | Natural | Bird or mammal | In vitro | Human dermal fibroblasts | Skin aging | Improves skin aging or skin wrinkles |
| AAPeptide042 | SIRT6 activating peptide | US 10022314 B2 | 2018 | Natural | Human | In vitro | Human dermal fibroblasts | Skin aging | Repairs skin cell DNA from UV damage |
| AAPeptide043 | 2n7-4 | US 10945940 B2, US 2018/0344608 A1 | 2021,2018 | Natural | Bird or mammal | In vitro | Human dermal fibroblasts | Skin aging | Improves skin aging or skin wrinkles |
| AAPeptide044 | 2n7-3 | US 10945940 B2, US 2018/0344608 A1 | 2021,2018 | Natural | Bird or mammal | In vitro | Human dermal fibroblasts | Skin aging | Improves skin aging or skin wrinkles |
| AAPeptide045 | 2-2 | US 10945940 B2, US 2018/0344608 A1 | 2021,2018 | Natural | Bird or mammal | In vitro | Human dermal fibroblasts | Skin aging | Improves skin aging or skin wrinkles |
| AAPeptide046 | KP7-1 | US 10945940 B2, US 2018/0344608 A1 | 2021,2018 | Natural | Bird or mammal | In vitro | Human dermal fibroblasts | Skin aging | Improves skin aging or skin wrinkles |
| AAPeptide047 | NA | NA | 2018 | Natural | Arthrospira (Spirulina) platensis | In vitro | Human erythrocyte, Human skin fibroblasts (HSFs) | Anti-oxiant and anti-aging component of functional food | Protects erythrocytes from lipid peroxidation and protein oxidation, Promotes cell proliferation and collagen production in UVB-pre-damaged human skin fibroblasts |
| AAPeptide048 | 2-1 | US 10945940 B2, US 2018/0344608 A1 | 2021,2018 | Natural | Bird or mammal | In vitro | Human dermal fibroblasts | Skin aging | Improves skin aging or skin wrinkles |
| AAPeptide049 | NA | US 10045925 B2 | 2018 | Synthetic | NA | In vitro, Randomized clinical trial | Human keratinocytes (HaCaT) | Skin aging | Skin brightening, Improves hydration and firmness |
| AAPeptide050 | NA | US 2018/0325794 A1, EP 3366694 A1, US 10478392 B2 | 2018,2019 | Natural | Human | In vitro | Human epidermal keratinocytes | Skin aging | Inhibites skin-wrinkle formation and skin-aging |
| AAPeptide051 | CTGF peptide fragment | US 9999649 B2 | 2018 | Natural | Human | In vitro | Human dermal fibroblast cells | Skin aging | Increases pro-collagen 1 and hyaluronic acid production |
| AAPeptide052 | KP7-2 | US 10945940 B2, US 2018/0344608 A1 | 2021,2018 | Natural | Bird or mammal | In vitro | Human dermal fibroblasts | Skin aging | Improves skin wrinkles |
| AAPeptide053 | ACT5 peptide | US 9855313 B2 | 2018 | Synthetic | NA | In vitro | Myocytes from neonatal rat hearts, WB-F344 cells (rat epithelial cell line) | Skin aging | Promotes skin healing, regeneration |
| AAPeptide054 | KF-8 | 32942847, 29276944 | 2018,2020 | Natural | Rice | In vitro, In vivo | Human umbilical vein endothelial cells (HUVECs), NIH/3T3 cells, Mice | Vascular endothelial cell (VEC) damage and oxidative stress injuries, D-Galactose induced aging | Reduces H2O2-induced oxidant injury, Ameliorates the Aging-Related Body Weight Loss and Increases Organ Coefficient, Mitigates the d-Gal-Induced Aortic and Brain Tissue Injury , Attenuates Oxidative Stress, Upregulates Nrf2 Antioxidant Signaling in the Livers, Inhibits NF-κB Signaling and Reduces Apoptosis-Related Regulator Expression |
| AAPeptide055 | GDF11 and TGFβ peptide fragment | US 9999649 B2 | 2018 | Natural | Human | In vitro | Human dermal fibroblast cells | Skin aging | Increase in hyaluronic acid production |
| AAPeptide056 | MOTS-c | 30967270, US 10064914 B2 | 2018,2019 | Synthetic | NA | In vitro, In vivo | C57BL/6 and Balb/c mice, HEK293 cells, HeLa cells | Metabolic dysfunctions associated with aging, D-Galactose induced aging | Decreases the level of Il-6, and increases collagen contents of the skin, Recovers mitochondrial dynamic changes |
| AAPeptide057 | GDF11 and TGFβ peptide fragment | US 9999649 B2 | 2018 | Natural | Human | In vitro | Human dermal fibroblast cells | Skin aging | Increase in hyaluronic acid production |
| AAPeptide058 | NA | US 2018/0360720 A1, US 10258556 B2 | 2018,2019 | Synthetic | NA | In vitro | CCD-966SK skin fibroblast cells | Skin aging | Enhances collagen and/or elastin levels, and the migration of the fibroblast cells |
| AAPeptide059 | 2n7-2 | US 10945940 B2, US 2018/0344608 A1 | 2021,2018 | Natural | Bird or mammal | In vitro | Human dermal fibroblasts | Skin aging | Improves skin wrinkles |
| AAPeptide060 | ACT2 peptide | US 9855313 B2 | 2018 | Synthetic | NA | In vitro | Myocytes from neonatal rat hearts, WB-F344 cells (rat epithelial cell line) | Skin aging | Promotes healing, regeneration |