AagingBase | Database of anti-aging peptide

AagingBase: Database of anti-aging peptides A manually curated comprehensive database for anti-aging peptides

Peptide Card for AAPeptide054

The Peptide Card page for AAPeptide054 gives textual and graphical visualizations of the properties of AAPeptide054. The users can find all the literature informations collected from scholarly articles and patents and the calculated physicochemical informations. There are also graphical representations hydropathy values, amino acid compositions and frequencies, atomic compositions and secondary structure fractions of AAPeptide054.
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AAP ID	AAPeptide054
Peptide name	KF-8
PubMed/Patent ID	32942847,29276944
Origin	Natural
Source of Origin	Rice
Condition addressed	Vascular endothelial cell (VEC) damage and oxidative stress injuries, D-Galactose induced aging
Experiment type	In vitro, In vivo
Cell lines/Animal model	Human umbilical vein endothelial cells (HUVECs), NIH/3T3 cells, Mice
Intervention	Cells were treated with the peptide., Mice were subcutaneously injected with the peptide.,Cells were treated with the peptide
Experiment methods	GST pulldown analysis, MTT cytotoxicity assay, Cell Apoptosis Assay, Co-immunoprecipitation, ELISA, Western blot, MDA,CAT,SOD and GSH-Px anti-oxidant enzyme activity, Histopathology, qRT-CR
Patient group	NA
Markers used	NA
Mechanism of action	Reduces H2O2-induced oxidant injury, Ameliorates the Aging-Related Body Weight Loss and Increases Organ Coefficient, Mitigates the d-Gal-Induced Aortic and Brain Tissue Injury , Attenuates Oxidative Stress, Upregulates Nrf2 Antioxidant Signaling in the Livers, Inhibits NF-κB Signaling and Reduces Apoptosis-Related Regulator Expression

Molecular weight	1002.042
Peptide length	8
Instability index	27.738
Aromaticity	0.125
Aliphaticity	0.125
Reduced molecular extinction coeffecient	0
Oxidized molecular extinction coeffecient	0
Isoelectric point	6.752
Composition of positively charged residues	0.375
Composition of negatively charged residues	0.250
Composition of neutral charged residues	0.375
Composition of residues polar residues	0.000
Composition of residues non-polar residues	0.250
Composition of residues having cyclic side chain	0.000
Composition of acidic residues	0.250
Composition of basic residues	0.375
Composition of residues having cyclic side chain	0.000
Composition of hydroxylic residues	0.000
Composition of residue in buried solvent accessibility	0.250
Composition of residue in exposed solvent accessibility	0.500
Composition of residue in intermediate solvent accessibility	0.125

AAPeptide054 :

KHNRGDEF

Amino acid data

ProtScale

Disclaimer: Hydropathy plot is not available for AAPeptide054 as the peptide length is less than 9 amino acid residues

Atomic information

3D Structure

Structural Representation of AAPeptide054

Amino acid data

Secondary structure fraction