AagingBase | Database of anti-aging peptide

AagingBase: Database of anti-aging peptides A manually curated comprehensive database for anti-aging peptides

Peptide Card for AAPeptide056

The Peptide Card page for AAPeptide056 gives textual and graphical visualizations of the properties of AAPeptide056. The users can find all the literature informations collected from scholarly articles and patents and the calculated physicochemical informations. There are also graphical representations hydropathy values, amino acid compositions and frequencies, atomic compositions and secondary structure fractions of AAPeptide056.
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AAP ID	AAPeptide056
Peptide name	MOTS-c
PubMed/Patent ID	30967270,US 10064914 B2
Origin	Synthetic
Source of Origin	NA
Condition addressed	Metabolic dysfunctions associated with aging, D-Galactose induced aging
Experiment type	In vitro, In vivo
Cell lines/Animal model	C57BL/6 and Balb/c mice, HEK293 cells, HeLa cells
Intervention	Intraperitoneal injections of the peptide to D-galactose treated mice.,Cells were treated with the peptide, Mice were treated with MOTS-c
Experiment methods	Immunostaining, Glucose and Lactate Assay, Glucose Tolerance Test (GTT), Oxygen Consumption and Extracellular Acidification Rate, Hyperinsulinemic-Euglycemic Clamp Studies, Histopathology, qPCR
Patient group	NA
Markers used	NA
Mechanism of action	Decreases the level of Il-6, and increases collagen contents of the skin, Recovers mitochondrial dynamic changes

Molecular weight	2174.592
Peptide length	16
Instability index	77.301
Aromaticity	0.250
Aliphaticity	0.250
Reduced molecular extinction coeffecient	8480
Oxidized molecular extinction coeffecient	8480
Isoelectric point	10.266
Composition of positively charged residues	0.250
Composition of negatively charged residues	0.062
Composition of neutral charged residues	0.688
Composition of residues polar residues	0.188
Composition of residues non-polar residues	0.500
Composition of residues having cyclic side chain	0.062
Composition of acidic residues	0.062
Composition of basic residues	0.250
Composition of residues having cyclic side chain	0.062
Composition of hydroxylic residues	0.000
Composition of residue in buried solvent accessibility	0.312
Composition of residue in exposed solvent accessibility	0.250
Composition of residue in intermediate solvent accessibility	0.312

AAPeptide056 :

MRWQEMGYIFYPRKLR

Amino acid data

ProtScale

Atomic information

3D Structure

Structural Representation of AAPeptide056

Amino acid data

Secondary structure fraction