AagingBase: Database of anti-aging peptides
A manually curated comprehensive database for anti-aging peptidesThe Literature info page of AAPeptide gives experimental informations of anti-aging peptides of AagingBase that were collected from scholarly articles and patents. Users can find the data in a filterable and sortable table. To obtain further details, refer to the Help page.
| AAP_ID | Reported name | ID | Year | Origin | Source | Experiment type | Cell lines/Animal model | Condition addressed | Bioactivity |
|---|---|---|---|---|---|---|---|---|---|
| AAPeptide241 | NA | US 2021/0017240 A1 | 2021 | Natural | Sunflower seed | In vitro | Human A549 cells | Oxidative stress, Anti-aging component of functional food | Reduces blood pressure and inflammation, Enhances immune activity, Decreases reactive oxidants, Induces vasodilation, Inhibits the activity of angiotensin converting enzyme (ACE), Activates NAD(P)H:quinone reductase (QR) in the subject, Activates nuclear factor erythroid 2 (NFE2)-related factor 2 (Nrf2) |
| AAPeptide242 | Chondroitin sulfate proteoglycan (CSPG) reduction peptide (CRP) | US 10906949 B2 | 2021 | NA | NA | In vitro, In vivo | Neu7 astrocytes, Rat model | Nervous system injuries (spinal cord injury (SCI)) caused by trauma or neurodegeneration or aging | Improves locomotion and bladder electromyography (EMG) activities, Increases sprouting/regeneration of axons including serotonin (5-HT) and anterogradely traced fibers from brain stem and red nuclei, the critical pathways regulating both locomotion and bladder functions, Could be applied to limb transplants, Improves motor function and bladder functions, Treats neurodegenerative disorders such as MS and related conditions |
| AAPeptide243 | NA | US 2021/0009637 A1 | 2021 | Natural | Jelly fish (such as Chironex fleckeri), Sea anemone (such as Heteractis magnifica), Spider (such as Latrodectus mactans), Octopus (such as Hapalochlaena maculosa). | In vitro | Human fibroblast cell line (CCD-966SK) | Skin aging | Decreases collagen breakdown, Increases production of collagen, elastin and/or hyaluronic acid, Retards aging, Improves skin and inhibits inflammation |
| AAPeptide244 | NA | US 10905734 B2 | 2021 | Synthetic | NA | In vitro | Human Dermal Fibroblasts (HDF) | Skin aging, Anti aging component of functional food | Slows skin aging, Treats of a wound in a mammal, a disease or condition characterised by damaged epithelial cells or tissue, Restores gut health and muscle health in a mammal |
| AAPeptide245 | NA | US 11155579 B2, US 2021/0009637 A1 | 2021 | Natural | Jelly fish (such as Chironex fleckeri), Sea anemone (such as Heteractis magnifica), Spider (such as Latrodectus mactans), Octopus (such as Hapalochlaena maculosa). | In vitro | Human fibroblast cell line (CCD-966SK) | Skin aging | Decreases collagen breakdown, Increases the production of collagen, elastin and/or hyaluronic acid, Retards aging, Improves skin and inhibits inflammation |
| AAPeptide246 | P11-4 or oligopeptide 104 | US 11154470 B1 | 2021 | Natural | Rhododendron, Leontopodium | Randomized clinical trial | NA | Inflammation and gum aging | Tooth whitening as well as a method of treating periodontal disease, and/or for eliminating or reducing the number of senescent cells in the gums of a subject, Rejuvenates gums, Potential loose teeth stabilized, and the well-being is increased |
| AAPeptide247 | NA | US 2021/0009637 A1 | 2021 | Natural | Jelly fish (such as Chironex fleckeri), Sea anemone (such as Heteractis magnifica), Spider (such as Latrodectus mactans), Octopus (such as Hapalochlaena maculosa). | In vitro | Human fibroblast cell line (CCD-966SK) | Skin aging | Decreases collagen breakdown, Increases the production of collagen, elastin and/or hyaluronic acid, Retards aging, Improves skin and inhibits inflammation |
| AAPeptide248 | NA | US 2021/0009637 A1 | 2021 | Natural | Jelly fish (such as Chironex fleckeri), Sea anemone (such as Heteractis magnifica), Spider (such as Latrodectus mactans), Octopus (such as Hapalochlaena maculosa). | In vitro | Human fibroblast cell line (CCD-966SK) | Skin aging | Decreases collagen breakdown, Increases the production of collagen, elastin and/or hyaluronic acid, Retards aging, Improves skin and inhibits inflammation |
| AAPeptide249 | NA | US 2021/0009637 A1 | 2021 | Natural | Jelly fish (such as Chironex fleckeri), Sea anemone (such as Heteractis magnifica), Spider (such as Latrodectus mactans), Octopus (such as Hapalochlaena maculosa). | In vitro | Human fibroblast cell line (CCD-966SK) | Skin aging | Decreases collagen breakdown, Increases the production of collagen, elastin and/or hyaluronic acid, Retards aging, Improves skin and inhibits inflammation |
| AAPeptide250 | NA | US 2021/0017240 A1 | 2021 | Natural | Sunflower seed | In vitro | Human A549 cells | Oxidative stress, Anti aging component of functional food | Reduces blood pressure, inflammation, Enhances immune activity, Decreases reactive oxidants, Induces vasodilation, Improves, Reduces the activity of angiotensin converting enzyme (ACE), Activates NAD(P)H:quinone reductase (QR), Reduces expression of mRNA for renin, Induces a drug-metabolizing enzyme, Activates nuclear factor erythroid 2 (NFE2)-related factor 2 (Nrf2) |
| AAPeptide251 | TELODIN (ST8) | US 11246818 B2, US 2021/0040152 A1 | 2021,2022 | Natural | Human | In vitro, In vivo | Human cervical carcinoma cells (Hela), 3-6 month old wild mice | Skin aging | Alleviates the respiratory dysfunction in mice, Reduces the expression of TPP1, the telomere shortening, Decreases the proportion of type II epithelial cells and pulmonary fibrosis caused by the overexpression of FBW7, Inhibits the telomere DNA damage caused by irradiation of X rays |
| AAPeptide252 | NA | US 11433013 B2, US 2021/0205200 A1 | 2021,2022 | Synthetic | NA | In vitro | Human keratinocytes(HaCaT cells), NIH3T3 cells (mouse fibroblasts), Human alveolar epithelial cells | Skin aging | Inhibits the inflow of pollutants such as dioxin, particulate matter, and cigarette smoke into skin, Regulates the expression of a skin aging-related gene, and thus may be effectively used as an active ingredient of a pharmaceutical composition for preventing or treating cancer, skin diseases, and lung diseases, which are caused by pollutants, or skin aging-related diseases, or as an active ingredient of a cosmetic composition for preventing skin damage caused by pollutants |
| AAPeptide253 | NA | US 2021/0017240 A1 | 2021 | Natural | Sunflower seed | In vitro | Human A549 cells | Oxidative stress, Anti aging component of functional food | Reduces blood pressure, inflammation, Enhances immune activity, Decreases reactive oxidants, Induces vasodilation, Improves, Reduces the activity of angiotensin converting enzyme (ACE), Activates NAD(P)H:quinone reductase (QR), Reduces expression of mRNA for renin, Induces a drug-metabolizing enzyme, Activates nuclear factor erythroid 2 (NFE2)-related factor 2 (Nrf2) |
| AAPeptide254 | NA | US 2021/0009637 A1 | 2021 | Natural | Jelly fish (such as Chironex fleckeri), Sea anemone (such as Heteractis magnifica), Spider (such as Latrodectus mactans), Octopus (such as Hapalochlaena maculosa). | In vitro | Human fibroblast cell line (CCD-966SK) | Skin aging | Decreases collagen breakdown, Increases the production of collagen, elastin and/or hyaluronic acid, Retards aging, Improves skin and inhibits inflammation |
| AAPeptide255 | ATF3 Protein-Binding Peptide | US 2021/0355164 A1 | 2021 | Synthetic | NA | In vitro, In vivo | HepG2 cells, C57BL/6J mice | Skin aging | Addresses oxidative stress, skin diseases, skin aging, damage caused by UV irradiation |
| AAPeptide256 | Hexapeptide-12 | US 11052032 B2 | 2021 | Synthetic | NA | In vitro, In vivo, Randomized clinical trial | Dermal fibroblasts, 3T3-L1 adipocytes | Aging associated skin laxity | Improves skin laxity, texture, or crepiness or body contouring |
| AAPeptide257 | NA | US 2021/0009637 A1 | 2021 | Natural | Jelly fish (such as Chironex fleckeri), Sea anemone (such as Heteractis magnifica), Spider (such as Latrodectus mactans), Octopus (such as Hapalochlaena maculosa). | In vitro | Human fibroblast cell line (CCD-966SK) | Skin aging | Decreases collagen breakdown, Increases the production of collagen, elastin and/or hyaluronic acid, Retards aging, Improves skin and inhibits inflammation |
| AAPeptide258 | ATF3 Protein-Binding Peptide | US 2021/0355164 A1 | 2021 | Synthetic | NA | In vitro, In vivo | HepG2 cells, C57BL/6J mice | Skin aging | Addresses oxidative stress, skin diseases, skin aging, damage caused by UV irradiation |
| AAPeptide259 | Pine nut protein hydrolysate (PNPH)-P11 | 33289247 | 2021 | Natural | Pinus yunnanensis Franch | In vitro, In vivo | HepG2 cells, SPF Kunming mice | D-Galactose induced aging | Have potential application prospects in the field of natural antioxidants and anti-aging functional foods |
| AAPeptide260 | Tmem100 mutant polypeptide | US 11066455 B2 | 2021 | Natural | Mus musculus | In vivo | Mice | Pain occuring with aging | Enhances TRPA1 Activity |