AagingBase | Database of anti-aging peptide

AagingBase: Database of anti-aging peptides A manually curated comprehensive database for anti-aging peptides

Peptide Card for AAPeptide252

The Peptide Card page for AAPeptide252 gives textual and graphical visualizations of the properties of AAPeptide252. The users can find all the literature informations collected from scholarly articles and patents and the calculated physicochemical informations. There are also graphical representations hydropathy values, amino acid compositions and frequencies, atomic compositions and secondary structure fractions of AAPeptide252.
To obtain further details, refer to the Help page.

AAP ID	AAPeptide252
Peptide name	NA
PubMed/Patent ID	US 11433013 B2,US 2021/0205200 A1
Origin	Synthetic
Source of Origin	NA
Condition addressed	Skin aging
Experiment type	In vitro
Cell lines/Animal model	Human keratinocytes(HaCaT cells), NIH3T3 cells (mouse fibroblasts), Human alveolar epithelial cells
Intervention	Cells were treated with the peptide
Experiment methods	Western blot, qRT-PCR
Patient group	NA
Markers used	SIRT1 (Anti-Aging Gene), p-Akt and p-ERK, CYP1A1, COX-2, and MMP-1
Mechanism of action	Inhibits the inflow of pollutants such as dioxin, particulate matter, and cigarette smoke into skin, Regulates the expression of a skin aging-related gene, and thus may be effectively used as an active ingredient of a pharmaceutical composition for preventing or treating cancer, skin diseases, and lung diseases, which are caused by pollutants, or skin aging-related diseases, or as an active ingredient of a cosmetic composition for preventing skin damage caused by pollutants

Molecular weight	1160.361
Peptide length	10
Instability index	0.510
Aromaticity	0.300
Aliphaticity	0.400
Reduced molecular extinction coeffecient	1490
Oxidized molecular extinction coeffecient	1490
Isoelectric point	8.310
Composition of positively charged residues	0.100
Composition of negatively charged residues	0.000
Composition of neutral charged residues	0.900
Composition of residues polar residues	0.300
Composition of residues non-polar residues	0.600
Composition of residues having cyclic side chain	0.000
Composition of acidic residues	0.000
Composition of basic residues	0.100
Composition of residues having cyclic side chain	0.000
Composition of hydroxylic residues	0.200
Composition of residue in buried solvent accessibility	0.600
Composition of residue in exposed solvent accessibility	0.100
Composition of residue in intermediate solvent accessibility	0.300

AAPeptide252 :

SYSGVLFFLK

Amino acid data

ProtScale

Atomic information

3D Structure

Structural Representation of AAPeptide252

Amino acid data

Secondary structure fraction