AagingBase | Database of anti-aging peptide

AagingBase: Database of anti-aging peptides A manually curated comprehensive database for anti-aging peptides

Peptide Card for AAPeptide251

The Peptide Card page for AAPeptide251 gives textual and graphical visualizations of the properties of AAPeptide251. The users can find all the literature informations collected from scholarly articles and patents and the calculated physicochemical informations. There are also graphical representations hydropathy values, amino acid compositions and frequencies, atomic compositions and secondary structure fractions of AAPeptide251.
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AAP ID	AAPeptide251
Peptide name	TELODIN (ST8)
PubMed/Patent ID	US 11246818 B2,US 2021/0040152 A1
Origin	Natural
Source of Origin	Human
Condition addressed	Skin aging
Experiment type	In vitro, In vivo
Cell lines/Animal model	Human cervical carcinoma cells (Hela), 3-6 month old wild mice
Intervention	Cells were treated with the peptide, Topical application of the peptide on the mice after X-ray irradiation,Mice were intratracheally perfused with the peptide, Cells were treated with the peptide
Experiment methods	qRT-PCR, Immunofluorescence assay, Western Blot, Masson and H&E staining, Fluorescence in situ hybridization (FISH)
Patient group	NA
Markers used	α-SMA, Col6α and MMP4,α-SMA, Col6a, and MMP3
Mechanism of action	Alleviates the respiratory dysfunction in mice, Reduces the expression of TPP1, the telomere shortening, Decreases the proportion of type II epithelial cells and pulmonary fibrosis caused by the overexpression of FBW7, Inhibits the telomere DNA damage caused by irradiation of X rays

Molecular weight	892.868
Peptide length	8
Instability index	83.675
Aromaticity	0.000
Aliphaticity	0.125
Reduced molecular extinction coeffecient	0
Oxidized molecular extinction coeffecient	0
Isoelectric point	4.529
Composition of positively charged residues	0.125
Composition of negatively charged residues	0.250
Composition of neutral charged residues	0.625
Composition of residues polar residues	0.375
Composition of residues non-polar residues	0.125
Composition of residues having cyclic side chain	0.000
Composition of acidic residues	0.250
Composition of basic residues	0.125
Composition of residues having cyclic side chain	0.000
Composition of hydroxylic residues	0.375
Composition of residue in buried solvent accessibility	0.125
Composition of residue in exposed solvent accessibility	0.375
Composition of residue in intermediate solvent accessibility	0.375

AAPeptide251 :

SRNGTEET

Amino acid data

ProtScale

Disclaimer: Hydropathy plot is not available for AAPeptide251 as the peptide length is less than 9 amino acid residues

Atomic information

3D Structure

Structural Representation of AAPeptide251

Amino acid data

Secondary structure fraction