AagingBase | Database of anti-aging peptide

AagingBase: Database of anti-aging peptides A manually curated comprehensive database for anti-aging peptides

Peptide Card for AAPeptide254

The Peptide Card page for AAPeptide254 gives textual and graphical visualizations of the properties of AAPeptide254. The users can find all the literature informations collected from scholarly articles and patents and the calculated physicochemical informations. There are also graphical representations hydropathy values, amino acid compositions and frequencies, atomic compositions and secondary structure fractions of AAPeptide254.
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AAP ID	AAPeptide254
Peptide name	NA
PubMed/Patent ID	US 2021/0009637 A1
Origin	Natural
Source of Origin	Jelly fish (such as Chironex fleckeri), Sea anemone (such as Heteractis magnifica), Spider (such as Latrodectus mactans), Octopus (such as Hapalochlaena maculosa).
Condition addressed	Skin aging
Experiment type	In vitro
Cell lines/Animal model	Human fibroblast cell line (CCD-966SK)
Intervention	Cells were treated with the peptide
Experiment methods	Assay in Increasing Expression of Genes
Patient group	NA
Markers used	NADSYN,Atg1, Ubl-5,FOXO,MRPS5, CCT2 and/or CCT8(Anti-aging gene), TERC(Telomerase genes), ERCC1,UNG, MSH6, XRCCS and/or MSH6(DNA repair genes), SMPD1,ELG-F and GBA(Moisture-retention related genes), collagen I gene, collagen IV gene, elastin genes, TIMP1, MMP-1
Mechanism of action	Decreases collagen breakdown, Increases the production of collagen, elastin and/or hyaluronic acid, Retards aging, Improves skin and inhibits inflammation

Molecular weight	666.766
Peptide length	6
Instability index	-5.817
Aromaticity	0.167
Aliphaticity	0.167
Reduced molecular extinction coeffecient	0
Oxidized molecular extinction coeffecient	0
Isoelectric point	10.001
Composition of positively charged residues	0.333
Composition of negatively charged residues	0.000
Composition of neutral charged residues	0.667
Composition of residues polar residues	0.333
Composition of residues non-polar residues	0.333
Composition of residues having cyclic side chain	0.000
Composition of acidic residues	0.000
Composition of basic residues	0.333
Composition of residues having cyclic side chain	0.000
Composition of hydroxylic residues	0.333
Composition of residue in buried solvent accessibility	0.333
Composition of residue in exposed solvent accessibility	0.333
Composition of residue in intermediate solvent accessibility	0.333

AAPeptide254 :

TKSGKF

Amino acid data

ProtScale

Disclaimer: Hydropathy plot is not available for AAPeptide254 as the peptide length is less than 9 amino acid residues

Atomic information

3D Structure

Structural Representation of AAPeptide254

Amino acid data

Secondary structure fraction