AagingBase | Database of anti-aging peptide

AagingBase: Database of anti-aging peptides A manually curated comprehensive database for anti-aging peptides

Peptide Card for AAPeptide063

The Peptide Card page for AAPeptide063 gives textual and graphical visualizations of the properties of AAPeptide063. The users can find all the literature informations collected from scholarly articles and patents and the calculated physicochemical informations. There are also graphical representations hydropathy values, amino acid compositions and frequencies, atomic compositions and secondary structure fractions of AAPeptide063.
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AAP ID	AAPeptide063
Peptide name	MyD88 inhibitor
PubMed/Patent ID	EP 3366302 A1
Origin	Synthetic
Source of Origin	NA
Condition addressed	Age-related macular degeneration
Experiment type	In vitro, In vivo, Ex vivo
Cell lines/Animal model	Primary mouse RPE cells, HeLa cells, THP-1 cells, Wild-type C57BL/6J mice
Intervention	Cells were transfected with plasmid containing peptide siRNA sense, Subretinal injections of the peptide in mice
Experiment methods	Immunostaining, Western blot, MTS Cell viability and cytotoxicity assay, H2DCFDA ROS assay, RNA-binding protein immunoprecipitation (RIP), ELISA , Caspase-8 activity assessment
Patient group	Donor eyes or ocular tissues from patients with geographic atrophy due to AMD or age-matched patients without AMD
Markers used	NA
Mechanism of action	Cell protection

Molecular weight	698.768
Peptide length	7
Instability index	53.714
Aromaticity	0.000
Aliphaticity	0.714
Reduced molecular extinction coeffecient	0
Oxidized molecular extinction coeffecient	0
Isoelectric point	5.836
Composition of positively charged residues	0.143
Composition of negatively charged residues	0.143
Composition of neutral charged residues	0.714
Composition of residues polar residues	0.000
Composition of residues non-polar residues	0.714
Composition of residues having cyclic side chain	0.143
Composition of acidic residues	0.143
Composition of basic residues	0.143
Composition of residues having cyclic side chain	0.143
Composition of hydroxylic residues	0.000
Composition of residue in buried solvent accessibility	0.571
Composition of residue in exposed solvent accessibility	0.286
Composition of residue in intermediate solvent accessibility	0.143

AAPeptide063 :

RDVVPGG

Amino acid data

ProtScale

Disclaimer: Hydropathy plot is not available for AAPeptide063 as the peptide length is less than 9 amino acid residues

Atomic information

3D Structure

Structural Representation of AAPeptide063

Amino acid data

Secondary structure fraction