AagingBase | Database of anti-aging peptide

Peptide Card for AAPeptide063


The Peptide Card page for AAPeptide063 gives textual and graphical visualizations of the properties of AAPeptide063. The users can find all the literature informations collected from scholarly articles and patents and the calculated physicochemical informations. There are also graphical representations hydropathy values, amino acid compositions and frequencies, atomic compositions and secondary structure fractions of AAPeptide063.
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AAP IDAAPeptide063
Peptide nameMyD88 inhibitor
PubMed/Patent IDEP 3366302 A1
OriginSynthetic
Source of OriginNA
Condition addressedAge-related macular degeneration
Experiment typeIn vitro, In vivo, Ex vivo
Cell lines/Animal modelPrimary mouse RPE cells, HeLa cells, THP-1 cells, Wild-type C57BL/6J mice
InterventionCells were transfected with plasmid containing peptide siRNA sense, Subretinal injections of the peptide in mice
Experiment methodsImmunostaining, Western blot, MTS Cell viability and cytotoxicity assay, H2DCFDA ROS assay, RNA-binding protein immunoprecipitation (RIP), ELISA , Caspase-8 activity assessment
Patient groupDonor eyes or ocular tissues from patients with geographic atrophy due to AMD or age-matched patients without AMD
Markers usedNA
Mechanism of actionCell protection
Molecular weight698.768
Peptide length7
Instability index53.714
Aromaticity0.000
Aliphaticity0.714
Reduced molecular extinction coeffecient0
Oxidized molecular extinction coeffecient0
Isoelectric point5.836
Composition of positively charged residues0.143
Composition of negatively charged residues0.143
Composition of neutral charged residues0.714
Composition of residues polar residues0.000
Composition of residues non-polar residues0.714
Composition of residues having cyclic side chain0.143
Composition of acidic residues0.143
Composition of basic residues0.143
Composition of residues having cyclic side chain0.143
Composition of hydroxylic residues0.000
Composition of residue in buried solvent accessibility0.571
Composition of residue in exposed solvent accessibility0.286
Composition of residue in intermediate solvent accessibility0.143

AAPeptide063 :
RDVVPGG

Amino acid data
ProtScale


Disclaimer: Hydropathy plot is not available for AAPeptide063 as the peptide length is less than 9 amino acid residues

Atomic information


3D Structure

Structural Representation of AAPeptide063

Amino acid data
Secondary structure fraction