AagingBase | Database of anti-aging peptide

Peptide Card for AAPeptide063

The Peptide Card page for AAPeptide063 gives textual and graphical visualizations of the properties of AAPeptide063. The users can find all the literature informations collected from scholarly articles and patents and the calculated physicochemical informations. There are also graphical representations hydropathy values, amino acid compositions and frequencies, atomic compositions and secondary structure fractions of AAPeptide063.
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AAP IDAAPeptide063
Peptide nameMyD88 inhibitor
PubMed/Patent IDEP 3366302 A1
OriginSynthetic
Source of OriginNA
Condition addressedAge-related macular degeneration
Experiment typeIn vitro, In vivo, Ex vivo
Cell lines/Animal modelPrimary mouse RPE cells, HeLa cells, THP-1 cells, Wild-type C57BL/6J mice
InterventionCells were transfected with plasmid containing peptide siRNA sense, Subretinal injections of the peptide in mice
Experiment methodsImmunostaining, Western blot, MTS Cell viability and cytotoxicity assay, H2DCFDA ROS assay, RNA-binding protein immunoprecipitation (RIP), ELISA , Caspase-8 activity assessment
Patient groupDonor eyes or ocular tissues from patients with geographic atrophy due to AMD or age-matched patients without AMD
Markers usedNA
Mechanism of actionCell protection
Amino acid data
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Disclaimer: Hydropathy plot is not available for AAPeptide063 as the peptide length is less than 9 amino acid residues

Atomic information
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3D Structure

Structural Representation of AAPeptide063

Amino acid data
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Secondary structure fraction
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Mpgyi