AagingBase | Database of anti-aging peptide

AagingBase: Database of anti-aging peptides A manually curated comprehensive database for anti-aging peptides

Peptide Card for AAPeptide082

The Peptide Card page for AAPeptide082 gives textual and graphical visualizations of the properties of AAPeptide082. The users can find all the literature informations collected from scholarly articles and patents and the calculated physicochemical informations. There are also graphical representations hydropathy values, amino acid compositions and frequencies, atomic compositions and secondary structure fractions of AAPeptide082.
To obtain further details, refer to the Help page.

AAP ID	AAPeptide082
Peptide name	L1-12
PubMed/Patent ID	31081964
Origin	Synthetic
Source of Origin	NA
Condition addressed	Oxidative stress
Experiment type	In vitro
Cell lines/Animal model	HepG2 cell line
Intervention	Cells were treated with the peptide
Experiment methods	DCFH‐DA ROS assay, Lifespan assay, Stress resistance assays aginst UV radiation, thermal shock and oxidative stress, RT-PCR
Patient group	NA
Markers used	NA
Mechanism of action	Enhances the expressions of the Cat‐1 and Nhr‐8 genes to reduce oxidative damage, leading to an extension of the lifespan, Activates Nhr‐8 resulting to degrade toxic substances, Increases the expression of antioxidant enzyme genes to resist stress, therefore extend lifespan.

Molecular weight	824.878
Peptide length	6
Instability index	23.067
Aromaticity	0.500
Aliphaticity	0.167
Reduced molecular extinction coeffecient	5500
Oxidized molecular extinction coeffecient	5500
Isoelectric point	4.050
Composition of positively charged residues	0.000
Composition of negatively charged residues	0.167
Composition of neutral charged residues	0.833
Composition of residues polar residues	0.000
Composition of residues non-polar residues	0.667
Composition of residues having cyclic side chain	0.167
Composition of acidic residues	0.167
Composition of basic residues	0.000
Composition of residues having cyclic side chain	0.167
Composition of hydroxylic residues	0.000
Composition of residue in buried solvent accessibility	0.500
Composition of residue in exposed solvent accessibility	0.500
Composition of residue in intermediate solvent accessibility	0.167

AAPeptide082 :

DFPWFN

Amino acid data

ProtScale

Disclaimer: Hydropathy plot is not available for AAPeptide082 as the peptide length is less than 9 amino acid residues

Atomic information

3D Structure

Structural Representation of AAPeptide082

Amino acid data

Secondary structure fraction