AagingBase | Database of anti-aging peptide

AagingBase: Database of anti-aging peptides A manually curated comprehensive database for anti-aging peptides

Peptide Card for AAPeptide147

The Peptide Card page for AAPeptide147 gives textual and graphical visualizations of the properties of AAPeptide147. The users can find all the literature informations collected from scholarly articles and patents and the calculated physicochemical informations. There are also graphical representations hydropathy values, amino acid compositions and frequencies, atomic compositions and secondary structure fractions of AAPeptide147.
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AAP ID	AAPeptide147
Peptide name	Casein‐derived peptide
PubMed/Patent ID	30592315
Origin	Natural
Source of Origin	Buffalo milk
Condition addressed	Cell aging
Experiment type	Ex vivo
Cell lines/Animal model	Skin fibroblasts
Intervention	Cells were treated with the peptide
Experiment methods	MTT cytotoxicity assay, DCFH‐DA ROS assay, Hoechst 33258 proliferation assay(D Damage), caspase-9/-3 apoptosis assay, SA‐β‐gal, Cell scratch assay, Sircol collagen assay, Western Blot
Patient group	NA
Markers used	SOD, CAT, GSH
Mechanism of action	Shows antiaging effect in prolonged serial passaged fibroblast cells, Causes activation and transmigration of Nrf2 for maintaining homeostasis, Rejuvenates the aged fibroblast cells by weakening the effects of the senescent associated secretory phenotype

Molecular weight	779.967
Peptide length	7
Instability index	118.629
Aromaticity	0.000
Aliphaticity	0.714
Reduced molecular extinction coeffecient	0
Oxidized molecular extinction coeffecient	0
Isoelectric point	8.720
Composition of positively charged residues	0.143
Composition of negatively charged residues	0.000
Composition of neutral charged residues	0.857
Composition of residues polar residues	0.143
Composition of residues non-polar residues	0.714
Composition of residues having cyclic side chain	0.286
Composition of acidic residues	0.000
Composition of basic residues	0.143
Composition of residues having cyclic side chain	0.286
Composition of hydroxylic residues	0.000
Composition of residue in buried solvent accessibility	0.429
Composition of residue in exposed solvent accessibility	0.571
Composition of residue in intermediate solvent accessibility	0.286

AAPeptide147 :

VLPVPQK

Amino acid data

ProtScale

Disclaimer: Hydropathy plot is not available for AAPeptide147 as the peptide length is less than 9 amino acid residues

Atomic information

3D Structure

Structural Representation of AAPeptide147

Amino acid data

Secondary structure fraction