AagingBase | Database of anti-aging peptide

AagingBase: Database of anti-aging peptides A manually curated comprehensive database for anti-aging peptides

Peptide Card for AAPeptide211

The Peptide Card page for AAPeptide211 gives textual and graphical visualizations of the properties of AAPeptide211. The users can find all the literature informations collected from scholarly articles and patents and the calculated physicochemical informations. There are also graphical representations hydropathy values, amino acid compositions and frequencies, atomic compositions and secondary structure fractions of AAPeptide211.
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AAP ID	AAPeptide211
Peptide name	α-Neoendorphin (NEP)
PubMed/Patent ID	32526201
Origin	Natural
Source of Origin	Human
Condition addressed	Skin aging and autophagy activation
Experiment type	In vitro
Cell lines/Animal model	Human dermal fibroblast cells
Intervention	Cells were treated with the peptide
Experiment methods	Immunocytochemical analysis, CM-H2DCF-DA assay, Western blot
Patient group	NA
Markers used	NA
Mechanism of action	Activates the kappa opioid receptor and exhibits certain anti-aging and anti-wrinkling effects, Increases the type I procollagen production, while decreasing MMP-1, MMP-2, and MMP-9 activities, Reduces UVB-induced photoaging by activating autophagy

Molecular weight	1228.441
Peptide length	10
Instability index	44.450
Aromaticity	0.300
Aliphaticity	0.400
Reduced molecular extinction coeffecient	2980
Oxidized molecular extinction coeffecient	2980
Isoelectric point	9.997
Composition of positively charged residues	0.300
Composition of negatively charged residues	0.000
Composition of neutral charged residues	0.700
Composition of residues polar residues	0.200
Composition of residues non-polar residues	0.500
Composition of residues having cyclic side chain	0.100
Composition of acidic residues	0.000
Composition of basic residues	0.300
Composition of residues having cyclic side chain	0.100
Composition of hydroxylic residues	0.000
Composition of residue in buried solvent accessibility	0.400
Composition of residue in exposed solvent accessibility	0.300
Composition of residue in intermediate solvent accessibility	0.300

AAPeptide211 :

YGGFLRKYPK

Amino acid data

ProtScale

Atomic information

3D Structure

Structural Representation of AAPeptide211

Amino acid data

Secondary structure fraction