AagingBase | Database of anti-aging peptide

AagingBase: Database of anti-aging peptides A manually curated comprehensive database for anti-aging peptides

Peptide Card for AAPeptide219

The Peptide Card page for AAPeptide219 gives textual and graphical visualizations of the properties of AAPeptide219. The users can find all the literature informations collected from scholarly articles and patents and the calculated physicochemical informations. There are also graphical representations hydropathy values, amino acid compositions and frequencies, atomic compositions and secondary structure fractions of AAPeptide219.
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AAP ID	AAPeptide219
Peptide name	Velvet antler polypeptide
PubMed/Patent ID	34645090
Origin	Natural
Source of Origin	Velvet antler
Condition addressed	D-Galactose induced aging
Experiment type	In vivo
Cell lines/Animal model	ICR mice
Intervention	NA
Experiment methods	H&E staining, Morris water maze (MWM) test, Biochemical analysis, Western blot, Hematoxylin-eosin (H&E) staining, Transmission electron microscopy (TEM), Detection of free fatty acid(FFA) levels in brain tissue, Detection of ATP content in brain tissue, MDA,CAT,SOD and GSH-PX anti-oxidant enzyme activity
Patient group	NA
Markers used	NA
Mechanism of action	Promotes the expression of CPT1A and ACOX1 by activating PPAR α, Regulates the intestinal flora of aging mice, thereby improving lipid metabolism in aging mice, Increases ATP and reduces the expression of APOE by reducing fatty acid content in the brain of aging mice, thereby improving the cognitive impairment caused by aging, Improving learning ability, and protecting neurons

Amino acid data

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ProtScale

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Atomic information

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3D Structure

Structural Representation of AAPeptide219

Amino acid data

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Secondary structure fraction

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Molecular weight	1479.654
Peptide length	14
Instability index	23.329
Aromaticity	0.000
Aliphaticity	0.571
Reduced molecular extinction coeffecient	0
Oxidized molecular extinction coeffecient	0
Isoelectric point	4.130
Composition of positively charged residues	0.071
Composition of negatively charged residues	0.214
Composition of neutral charged residues	0.714
Composition of residues polar residues	0.143
Composition of residues non-polar residues	0.571
Composition of residues having cyclic side chain	0.143
Composition of acidic residues	0.214
Composition of basic residues	0.071
Composition of residues having cyclic side chain	0.143
Composition of hydroxylic residues	0.071
Composition of residue in buried solvent accessibility	0.500
Composition of residue in exposed solvent accessibility	0.357
Composition of residue in intermediate solvent accessibility	0.286