AagingBase | Database of anti-aging peptide

AagingBase: Database of anti-aging peptides A manually curated comprehensive database for anti-aging peptides

Peptide Card for AAPeptide005

The Peptide Card page for AAPeptide005 gives textual and graphical visualizations of the properties of AAPeptide005. The users can find all the literature informations collected from scholarly articles and patents and the calculated physicochemical informations. There are also graphical representations hydropathy values, amino acid compositions and frequencies, atomic compositions and secondary structure fractions of AAPeptide005.
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AAP ID	AAPeptide005
Peptide name	GV1001
PubMed/Patent ID	24439482,US 10898540 B2,US 2019/0142894 A1,34649386,US 10227382 B2
Origin	Natural
Source of Origin	Human
Condition addressed	Cell aging, Neurotoxicity, Cell loss and senescence, Anti aging component of functional food, Focal cerebral ischemia-reperfusion injury (IRI)
Experiment type	In vitro, In vivo
Cell lines/Animal model	Neural Stem Cells from rodent embryonic brains, Primary cultured cortical neurons, Human neural stem cells (H9 hESC-derived),Male Sprague-Dawley rats, B6 transgenic mice
Intervention	Repurfusion of peptide into the mice after focal cerebral IRI was induced ,Subcutaneous injection of the peptide,Cells were treated with the peptide,Alzheimer transgenic mice (3XTg-AD) were administrated with the peptide
Experiment methods	Immunohistochemistry, Histopathology, Mitochondrial DNA damage assay, Mitochondrial membrane potential assay, Western blot, Cell Viability&Cytotoxicity test by TBS and LDH Release assay, BrdU cell proliferation assay, CFU assay, Cell migration assay, ATP assay, TUNEL Assay, ROS assay, MDA,CAT,SOD and GPX anti-oxidant enzyme activity, ELISA, TeloTAGGG telomerase PCR, TeloTAGGG telomere length assay, CCK-8 Cell cytotoxicity assay, MTT & LDH assay, Oxidative mitochondrial DNA damage assay, Immunocytochemistry, DCFH-DA ROS assay
Patient group	NA
Markers used	NA
Mechanism of action	Treats diseases induced by an abnormal decrease in telomerase activity, cellular senescence, and diseases associated with the loss of nervous cells and regeneration capability, Protectes NSCs, Improves mitochondrial function, Increases the levels of diverse intracellular proteins, such as elongation factor 1-delta, heat shock protein 90α, and ezrin in OGD/R-injured NCSs

Molecular weight	1868.230
Peptide length	16
Instability index	55.725
Aromaticity	0.062
Aliphaticity	0.500
Reduced molecular extinction coeffecient	0
Oxidized molecular extinction coeffecient	0
Isoelectric point	11.711
Composition of positively charged residues	0.250
Composition of negatively charged residues	0.062
Composition of neutral charged residues	0.688
Composition of residues polar residues	0.125
Composition of residues non-polar residues	0.562
Composition of residues having cyclic side chain	0.125
Composition of acidic residues	0.062
Composition of basic residues	0.250
Composition of residues having cyclic side chain	0.125
Composition of hydroxylic residues	0.125
Composition of residue in buried solvent accessibility	0.438
Composition of residue in exposed solvent accessibility	0.250
Composition of residue in intermediate solvent accessibility	0.250

AAPeptide005 :

EARPALLTSRLRFIPK

Amino acid data

ProtScale

Atomic information

3D Structure

Structural Representation of AAPeptide005

Amino acid data

Secondary structure fraction