AagingBase | Database of anti-aging peptide

AagingBase: Database of anti-aging peptides A manually curated comprehensive database for anti-aging peptides

Peptide Card for AAPeptide008

The Peptide Card page for AAPeptide008 gives textual and graphical visualizations of the properties of AAPeptide008. The users can find all the literature informations collected from scholarly articles and patents and the calculated physicochemical informations. There are also graphical representations hydropathy values, amino acid compositions and frequencies, atomic compositions and secondary structure fractions of AAPeptide008.
To obtain further details, refer to the Help page.

AAP ID	AAPeptide008
Peptide name	Hexapeptide-11
PubMed/Patent ID	US 11052032 B2,25974626,US 2019/0038539 A1
Origin	Synthetic
Source of Origin	NA
Condition addressed	Aging associated skin laxity, Oxidative stress induced cellular senescence
Experiment type	In vitro, In vivo, Randomized clinical trial
Cell lines/Animal model	Human lung embryonic (IMR90 cells), Human newborn foreskin (BJs) fibroblasts, Dermal fibroblasts, 3T3-L1 adipocytes
Intervention	Cells were treated with the peptide, Topical application of the formulation on a patient undergoing Coolsculpting,Cells were treated with the peptide after stress induction
Experiment methods	MMP2 MMP6 gelatin activity by gelatin zymography, Immunofluroscene staining, Cell migration assay, SA-β-gal assay, Immunoblotting, Gene expression profiling, Macrophage Clustering
Patient group	Women between 25 and 65 years of age to assess the efficacy of the regenerating body complex (RBC)
Markers used	NA
Mechanism of action	Induces the activity of extracellular MMPs, Activates the MMP-2/MMP-9 metalloproteinases and suppresses fibroblasts migration, Stimulates autophagy, promotes dose and time-dependent activation of proteasome, autophagy, chaperones and antioxidant responses related genes, Improves skin laxity, texture, or crepiness or body contouring

Molecular weight	676.802
Peptide length	6
Instability index	104.633
Aromaticity	0.333
Aliphaticity	0.667
Reduced molecular extinction coeffecient	0
Oxidized molecular extinction coeffecient	0
Isoelectric point	5.525
Composition of positively charged residues	0.000
Composition of negatively charged residues	0.000
Composition of neutral charged residues	1.000
Composition of residues polar residues	0.000
Composition of residues non-polar residues	1.000
Composition of residues having cyclic side chain	0.333
Composition of acidic residues	0.000
Composition of basic residues	0.000
Composition of residues having cyclic side chain	0.333
Composition of hydroxylic residues	0.000
Composition of residue in buried solvent accessibility	0.667
Composition of residue in exposed solvent accessibility	0.333
Composition of residue in intermediate solvent accessibility	0.333

AAPeptide008 :

FVAPFP

Amino acid data

ProtScale

Disclaimer: Hydropathy plot is not available for AAPeptide008 as the peptide length is less than 9 amino acid residues

Atomic information

3D Structure

Structural Representation of AAPeptide008

Amino acid data

Secondary structure fraction