AagingBase | Database of anti-aging peptide

Peptide Card for AAPeptide011

The Peptide Card page for AAPeptide011 gives textual and graphical visualizations of the properties of AAPeptide011. The users can find all the literature informations collected from scholarly articles and patents and the calculated physicochemical informations. There are also graphical representations hydropathy values, amino acid compositions and frequencies, atomic compositions and secondary structure fractions of AAPeptide011.
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AAP IDAAPeptide011
Peptide nameHumanin
PubMed/Patent ID35086467,26990160
OriginNatural
Source of OriginHuman
Condition addressedCell death, Late-onset Hypogonadism
Experiment typeIn vitro, In vivo
Cell lines/Animal modelMice,Human retinal pigment epithelial (hRPE) cells
InterventionAssessment of humanin localization in RPE cells using confocal microscopy,Intraperitonal injection of the peptide
Experiment methodsTUNEL staining, Detection of Mitochondrial Superoxide, Western blot, Mitochondrial DNA (mtDNA) Copy Number Measurement, SA-β-gal expression, Blood and serum parameter assay, H&E staining, Immunohistochemistry, ELISA, MDA, SOD, GSH-Px antioxidant enzyme activity
Patient groupNA
Markers usedIL-6 and TNF- α (inflammatory markers),ZO1 and occludin (tight junction markers), p16INK4a (senescent marker)
Mechanism of actionProtects RPE Cells From Oxidative Stress–Induced Cell Death, Re-establishes Mitochondrial function and biogenesis, Can treat age-related macular degeneration(AMD), maintain testicular health
Molecular weight2687.231
Peptide length24
Instability index106.029
Aromaticity0.042
Aliphaticity0.500
Reduced molecular extinction coeffecient0
Oxidized molecular extinction coeffecient0
Isoelectric point9.493
Composition of positively charged residues0.167
Composition of negatively charged residues0.083
Composition of neutral charged residues0.750
Composition of residues polar residues0.167
Composition of residues non-polar residues0.583
Composition of residues having cyclic side chain0.083
Composition of acidic residues0.083
Composition of basic residues0.167
Composition of residues having cyclic side chain0.083
Composition of hydroxylic residues0.125
Composition of residue in buried solvent accessibility0.500
Composition of residue in exposed solvent accessibility0.208
Composition of residue in intermediate solvent accessibility0.250

AAPeptide011 :
MAPRGFSCLLLLTSEIDLPVKRRA

Amino acid data
ProtScale
Atomic information


3D Structure

Structural Representation of AAPeptide011

Amino acid data
Secondary structure fraction