AagingBase | Database of anti-aging peptide

AagingBase: Database of anti-aging peptides A manually curated comprehensive database for anti-aging peptides

Peptide Card for AAPeptide003

The Peptide Card page for AAPeptide003 gives textual and graphical visualizations of the properties of AAPeptide003. The users can find all the literature informations collected from scholarly articles and patents and the calculated physicochemical informations. There are also graphical representations hydropathy values, amino acid compositions and frequencies, atomic compositions and secondary structure fractions of AAPeptide003.
To obtain further details, refer to the Help page.

AAP ID	AAPeptide003
Peptide name	Lipoic acid (LA)-peptide conjugate,
PubMed/Patent ID	24090916,US 9856290 B2,US 10071043 B2
Origin	Natural
Source of Origin	Human
Condition addressed	Melanogenesis, Skin aging
Experiment type	In vitro
Cell lines/Animal model	Human Dermal Fibroblast (HDF), Human Dermal Fibroblasts (KMST-6), Mouse melanoma B16F10 cells
Intervention	Cells were cultured in DMEM medium,Cells were treated with the peptide
Experiment methods	ELISA, MTS Cell Viability and Cytotoxicity Assay, Cell proliferation and DNA quantification, Apoptosis/Necrosis measurement, MTT cytotoxicity assay, H&E staining, Tyrosinase inhibition assay, Measurement of melanin content, Collagen synthesis assay, Gene Expression Analysis
Patient group	NA
Markers used	MMP-1
Mechanism of action	Increases ECM secretion (elastin and fibronectin), Enhances skin barrier function, Skin hydration, Possesses the ability to enhance dermal remodeling by triggering cellular processes, such as increasing ECM production

Molecular weight	563.645
Peptide length	5
Instability index	8.000
Aromaticity	0.000
Aliphaticity	0.000
Reduced molecular extinction coeffecient	0
Oxidized molecular extinction coeffecient	0
Isoelectric point	10.003
Composition of positively charged residues	0.400
Composition of negatively charged residues	0.000
Composition of neutral charged residues	0.600
Composition of residues polar residues	0.600
Composition of residues non-polar residues	0.000
Composition of residues having cyclic side chain	0.000
Composition of acidic residues	0.000
Composition of basic residues	0.400
Composition of residues having cyclic side chain	0.000
Composition of hydroxylic residues	0.600
Composition of residue in buried solvent accessibility	0.000
Composition of residue in exposed solvent accessibility	0.400
Composition of residue in intermediate solvent accessibility	0.600

AAPeptide003 :

KTTKS

Amino acid data

ProtScale

Disclaimer: Hydropathy plot is not available for AAPeptide003 as the peptide length is less than 9 amino acid residues

Atomic information

3D Structure

Structural Representation of AAPeptide003

Amino acid data

Secondary structure fraction