AagingBase | Database of anti-aging peptide

AagingBase: Database of anti-aging peptides A manually curated comprehensive database for anti-aging peptides

Peptide Card for AAPeptide015

The Peptide Card page for AAPeptide015 gives textual and graphical visualizations of the properties of AAPeptide015. The users can find all the literature informations collected from scholarly articles and patents and the calculated physicochemical informations. There are also graphical representations hydropathy values, amino acid compositions and frequencies, atomic compositions and secondary structure fractions of AAPeptide015.
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AAP ID	AAPeptide015
Peptide name	PYP1‑5
PubMed/Patent ID	27878236
Origin	Natural
Source of Origin	Pyropia yezoensis
Condition addressed	Skin aging
Experiment type	In vitro
Cell lines/Animal model	Human skin fibroblast cell line Hs27
Intervention	Cells were treated with the peptide
Experiment methods	Procollagen type I C-peptide (PIP) EIA assay, MTS cell viability assay, Western blot, qPCR
Patient group	NA
Markers used	NA
Mechanism of action	Promotes type I collagen synthesis, Increases elastin expression, Decreases MMP-1 expression and increases TIMP-1 and -2 expression, Increases the expression of specificity protein 1 (Sp1) transcription factor via the TGF-β/Smad signaling pathway

Molecular weight	1507.735
Peptide length	14
Instability index	64.129
Aromaticity	0.071
Aliphaticity	0.500
Reduced molecular extinction coeffecient	0
Oxidized molecular extinction coeffecient	0
Isoelectric point	10.019
Composition of positively charged residues	0.214
Composition of negatively charged residues	0.000
Composition of neutral charged residues	0.786
Composition of residues polar residues	0.214
Composition of residues non-polar residues	0.571
Composition of residues having cyclic side chain	0.143
Composition of acidic residues	0.000
Composition of basic residues	0.214
Composition of residues having cyclic side chain	0.143
Composition of hydroxylic residues	0.071
Composition of residue in buried solvent accessibility	0.429
Composition of residue in exposed solvent accessibility	0.429
Composition of residue in intermediate solvent accessibility	0.286

AAPeptide015 :

PKGKQQAIHVAPSF

Amino acid data

ProtScale

Atomic information

3D Structure

Structural Representation of AAPeptide015

Amino acid data

Secondary structure fraction