AagingBase | Database of anti-aging peptide

AagingBase: Database of anti-aging peptides A manually curated comprehensive database for anti-aging peptides

Peptide Card for AAPeptide265

The Peptide Card page for AAPeptide265 gives textual and graphical visualizations of the properties of AAPeptide265. The users can find all the literature informations collected from scholarly articles and patents and the calculated physicochemical informations. There are also graphical representations hydropathy values, amino acid compositions and frequencies, atomic compositions and secondary structure fractions of AAPeptide265.
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AAP ID	AAPeptide265
Peptide name	TELODIN (DKY21)
PubMed/Patent ID	US 11365217 B2,US 11246818 B2,US 2021/0040152 A1
Origin	Natural
Source of Origin	Human
Condition addressed	Skin aging
Experiment type	In vitro, In vivo
Cell lines/Animal model	Human cervical carcinoma cells (Hela), 3-6 month old wild mice
Intervention	Cells were treated with the peptide, Topical application of the peptide on the mice after X-ray irradiation,Mice were intratracheally perfused with the peptide, Cells were treated with the peptide
Experiment methods	qRT-PCR, Immunofluorescence assay, Western Blot, Masson and H&E staining, Fluorescence in situ hybridization (FISH)
Patient group	NA
Markers used	α-SMA, Col6α and MMP3,α-SMA, Col6α and MMP5,α-SMA
Mechanism of action	Alleviates the respiratory dysfunction in mice, Reduces the expression of TPP1, the telomere shortening, Decreases the proportion of type II epithelial cells and pulmonary fibrosis caused by the overexpression of FBW7, Inhibits the telomere DNA damage caused by irradiation of X rays

Molecular weight	2620.889
Peptide length	21
Instability index	127.333
Aromaticity	0.048
Aliphaticity	0.143
Reduced molecular extinction coeffecient	1490
Oxidized molecular extinction coeffecient	1490
Isoelectric point	11.630
Composition of positively charged residues	0.476
Composition of negatively charged residues	0.143
Composition of neutral charged residues	0.381
Composition of residues polar residues	0.190
Composition of residues non-polar residues	0.143
Composition of residues having cyclic side chain	0.000
Composition of acidic residues	0.143
Composition of basic residues	0.476
Composition of residues having cyclic side chain	0.000
Composition of hydroxylic residues	0.143
Composition of residue in buried solvent accessibility	0.143
Composition of residue in exposed solvent accessibility	0.333
Composition of residue in intermediate solvent accessibility	0.190

AAPeptide265 :

YGRKKRRERRRGSRNGTEETK

Amino acid data

ProtScale

Atomic information

3D Structure

Structural Representation of AAPeptide265

Amino acid data

Secondary structure fraction