AagingBase | Database of anti-aging peptide

AagingBase: Database of anti-aging peptides A manually curated comprehensive database for anti-aging peptides

Peptide Card for AAPeptide277

The Peptide Card page for AAPeptide277 gives textual and graphical visualizations of the properties of AAPeptide277. The users can find all the literature informations collected from scholarly articles and patents and the calculated physicochemical informations. There are also graphical representations hydropathy values, amino acid compositions and frequencies, atomic compositions and secondary structure fractions of AAPeptide277.
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AAP ID	AAPeptide277
Peptide name	NA
PubMed/Patent ID	US 11246818 B2
Origin	Synthetic
Source of Origin	NA
Condition addressed	Skin aging
Experiment type	In vitro, Ex vivo
Cell lines/Animal model	Primary human epidermal keratinocytes, Primary human epidermal melanocytes
Intervention	Cells were treated with the peptide
Experiment methods	ABTS decolorization assay, DPPH free radical scavenging assay, Thiobarbituric acid reactive substances (TBARS) assay, ELISA, Tyrosinase activity evaluation, MDA antioxidant enzyme activity, qRT-PCR
Patient group	Human skin explants from a 49-year-old Caucasian woman
Markers used	CYP2R1, NFE2L2, HMOX1, GSTP1 , GSS , GPX1 and TRX
Mechanism of action	Addresses skin imperfections associated with oxidative-stress, such as, skin complexion, pigmentation alterations, wrinkling and loss in skin density, tone and elasticity due to reduced amount of collagen or elastic fibers, loss in the structure of the extracellular matrix or structural lipids or DNA damage, Increases skin fragility and inflammatory response

Molecular weight	828.960
Peptide length	6
Instability index	3.533
Aromaticity	0.333
Aliphaticity	0.333
Reduced molecular extinction coeffecient	5500
Oxidized molecular extinction coeffecient	5500
Isoelectric point	9.757
Composition of positively charged residues	0.333
Composition of negatively charged residues	0.000
Composition of neutral charged residues	0.667
Composition of residues polar residues	0.000
Composition of residues non-polar residues	0.667
Composition of residues having cyclic side chain	0.000
Composition of acidic residues	0.000
Composition of basic residues	0.333
Composition of residues having cyclic side chain	0.000
Composition of hydroxylic residues	0.000
Composition of residue in buried solvent accessibility	0.667
Composition of residue in exposed solvent accessibility	0.000
Composition of residue in intermediate solvent accessibility	0.167

AAPeptide277 :

LHWFRA

Amino acid data

ProtScale

Disclaimer: Hydropathy plot is not available for AAPeptide277 as the peptide length is less than 9 amino acid residues

Atomic information

3D Structure

Structural Representation of AAPeptide277

Amino acid data

Secondary structure fraction