AagingBase | Database of anti-aging peptide

AagingBase: Database of anti-aging peptides A manually curated comprehensive database for anti-aging peptides

Peptide Card for AAPeptide279

The Peptide Card page for AAPeptide279 gives textual and graphical visualizations of the properties of AAPeptide279. The users can find all the literature informations collected from scholarly articles and patents and the calculated physicochemical informations. There are also graphical representations hydropathy values, amino acid compositions and frequencies, atomic compositions and secondary structure fractions of AAPeptide279.
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AAP ID	AAPeptide279
Peptide name	Basa skin collagen peptide
PubMed/Patent ID	US 11471395 B3
Origin	Natural
Source of Origin	Pangasius bocourti
Condition addressed	Skin aging
Experiment type	In vitro, In vivo
Cell lines/Animal model	Human fibroblasts (CCD-966SK)
Intervention	Cells were treated with the peptide
Experiment methods	qRT-PCR, 2-AACt quatification method, Mitochondria membrane potential detection, Measurement of skin conditions (such as skin pore percentage,skin moisture percentage,skin collagen density)
Patient group	Human, N=13(Control=6,Experiment=7)
Markers used	Atg8, CCT2, CCT5, CCT6A, CCT7, CCT8, Pink1, SIRT1 and Ubl-5(Anti-aging genes), COL3A1, COL4A4(Collagen genes), HAS2 and HAS3(Hyaluronan Synthase Genes)
Mechanism of action	Promotes the expression of at least one gene of an Atg8 gene, a CCT2 gene, a CCT5 gene, a CCT6A gene, a CCT7 gene, a CCT8 gene, a Pink1 gene, an STIR) gene, a Ubl-5 gene, a COL3A1 gene, a COL4A4 gene, an HAS2 gene and an HAS3 gene, Increases collagen content, Improves skin collagen density, skin moisture, minimizes skin pores and reduces wrinkles

Molecular weight	910.971
Peptide length	11
Instability index	28.673
Aromaticity	0.000
Aliphaticity	0.727
Reduced molecular extinction coeffecient	0
Oxidized molecular extinction coeffecient	0
Isoelectric point	9.180
Composition of positively charged residues	0.091
Composition of negatively charged residues	0.000
Composition of neutral charged residues	0.909
Composition of residues polar residues	0.182
Composition of residues non-polar residues	0.727
Composition of residues having cyclic side chain	0.273
Composition of acidic residues	0.000
Composition of basic residues	0.091
Composition of residues having cyclic side chain	0.273
Composition of hydroxylic residues	0.182
Composition of residue in buried solvent accessibility	0.455
Composition of residue in exposed solvent accessibility	0.364
Composition of residue in intermediate solvent accessibility	0.455

AAPeptide279 :

PGAPGSSGPKG

Amino acid data

ProtScale

Atomic information

3D Structure

Structural Representation of AAPeptide279

Amino acid data

Secondary structure fraction