AagingBase | Database of anti-aging peptide

AagingBase: Database of anti-aging peptides A manually curated comprehensive database for anti-aging peptides

Peptide Card for AAPeptide275

The Peptide Card page for AAPeptide275 gives textual and graphical visualizations of the properties of AAPeptide275. The users can find all the literature informations collected from scholarly articles and patents and the calculated physicochemical informations. There are also graphical representations hydropathy values, amino acid compositions and frequencies, atomic compositions and secondary structure fractions of AAPeptide275.
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AAP ID	AAPeptide275
Peptide name	Basa skin collagen peptide
PubMed/Patent ID	US 11471395 B2
Origin	Natural
Source of Origin	Pangasius bocourti
Condition addressed	Skin aging, Anti aging component of functional food
Experiment type	In vitro, In vivo
Cell lines/Animal model	Human fibroblasts (CCD-966SK)
Intervention	Cells were treated with the peptide
Experiment methods	qRT-PCR, 2-AACt quatification method, Mitochondria membrane potential detection, Measurement of skin conditions (such as skin pore percentage,skin moisture percentage,skin collagen density)
Patient group	Human, N=13(Control=6,Experiment=7)
Markers used	Atg8, CCT2, CCT5, CCT6A, CCT7, CCT8, Pink1, SIRT1 and Ubl-5(Anti-aging genes), COL3A1, COL4A4(Collagen genes), HAS2 and HAS3(Hyaluronan Synthase Genes)
Mechanism of action	Promotes the expression of at least one gene of an Atg8 gene, a CCT2 gene, a CCT5 gene, a CCT6A gene, a CCT7 gene, a CCT8 gene, a Pink1 gene, an STIR) gene, a Ubl-5 gene, a COL3A1 gene, a COL4A4 gene, an HAS2 gene and an HAS3 gene, Increases collagen content, Improves skin collagen density, skin moisture, minimizes skin pores and reduces wrinkles

Molecular weight	798.886
Peptide length	8
Instability index	2.950
Aromaticity	0.125
Aliphaticity	0.625
Reduced molecular extinction coeffecient	5500
Oxidized molecular extinction coeffecient	5500
Isoelectric point	8.750
Composition of positively charged residues	0.125
Composition of negatively charged residues	0.000
Composition of neutral charged residues	0.875
Composition of residues polar residues	0.125
Composition of residues non-polar residues	0.750
Composition of residues having cyclic side chain	0.250
Composition of acidic residues	0.000
Composition of basic residues	0.125
Composition of residues having cyclic side chain	0.250
Composition of hydroxylic residues	0.125
Composition of residue in buried solvent accessibility	0.500
Composition of residue in exposed solvent accessibility	0.375
Composition of residue in intermediate solvent accessibility	0.375

AAPeptide275 :

KGWPGTPG

Amino acid data

ProtScale

Disclaimer: Hydropathy plot is not available for AAPeptide275 as the peptide length is less than 9 amino acid residues

Atomic information

3D Structure

Structural Representation of AAPeptide275

Amino acid data

Secondary structure fraction