AagingBase | Database of anti-aging peptide

Peptide Card for AAPeptide274


The Peptide Card page for AAPeptide274 gives textual and graphical visualizations of the properties of AAPeptide274. The users can find all the literature informations collected from scholarly articles and patents and the calculated physicochemical informations. There are also graphical representations hydropathy values, amino acid compositions and frequencies, atomic compositions and secondary structure fractions of AAPeptide274.
To obtain further details, refer to the Help page.


AAP IDAAPeptide274
Peptide nameNA
PubMed/Patent IDUS 11246818 B2
OriginSynthetic
Source of OriginNA
Condition addressedSkin aging
Experiment typeIn vitro, Ex vivo
Cell lines/Animal modelPrimary human epidermal keratinocytes, Primary human epidermal melanocytes
InterventionCells were treated with the peptide
Experiment methodsABTS decolorization assay, DPPH free radical scavenging assay, Thiobarbituric acid reactive substances (TBARS) assay, ELISA, Tyrosinase activity evaluation, MDA antioxidant enzyme activity, qRT-PCR
Patient groupHuman skin explants from a 49-year-old Caucasian woman
Markers usedCYP2R1, NFE2L2, HMOX1, GSTP1 , GSS , GPX1 and TRX
Mechanism of actionAddresses skin imperfections associated with oxidative-stress, such as, skin complexion, pigmentation alterations, wrinkling and loss in skin density, tone and elasticity due to reduced amount of collagen or elastic fibers, loss in the structure of the extracellular matrix or structural lipids or DNA damage, Increases skin fragility and inflammatory response
Molecular weight616.711
Peptide length4
Instability index-37.275
Aromaticity0.500
Aliphaticity0.000
Reduced molecular extinction coeffecient5500
Oxidized molecular extinction coeffecient5500
Isoelectric point8.757
Composition of positively charged residues0.500
Composition of negatively charged residues0.000
Composition of neutral charged residues0.500
Composition of residues polar residues0.000
Composition of residues non-polar residues0.500
Composition of residues having cyclic side chain0.000
Composition of acidic residues0.000
Composition of basic residues0.500
Composition of residues having cyclic side chain0.000
Composition of hydroxylic residues0.000
Composition of residue in buried solvent accessibility0.500
Composition of residue in exposed solvent accessibility0.250
Composition of residue in intermediate solvent accessibility0.250

AAPeptide274 :
HWFK

Amino acid data
ProtScale


Disclaimer: Hydropathy plot is not available for AAPeptide274 as the peptide length is less than 9 amino acid residues

Atomic information


3D Structure

Structural Representation of AAPeptide274

Amino acid data
Secondary structure fraction