ZnF-Prot: Zinc finger motifs in proteome
Proteome wide automated prediction of zinc finger motifs
Click the above button for Zinc finger motif prediction
Proteome wide automated prediction of zinc finger motifs
Click the above button for Zinc finger motif prediction
The systematic zinc finger domain classification was carried out based on the references given below. User can click the link that is given below for detailed information.
Zinc-finger proteins in health and disease Metal binding properties, stability and reactivity of zinc fingers Caught with One's Zinc Fingers in the Genome Integrity Cookie Jar Structural classification of zinc fingers: SURVEY AND SUMMARY A comprehensive survey on the classification of zinc finger domains has been carried out to understand the structural variations of all available zinc finger domains. Based on existing zinc finger domain information from previous studies, 32 different classes of zinc finger (ZnF) domains have been classified. They are, C2H2, CCCH, Zinc ribbon, Zinc knuckle, TAZ domain, Zn2/Cys6, Treble clef (RING, PHD, LIM, B-box, HIT, MYND, ZZ, THAP, MYM, FYVE and PKC-DAG domains), CCHHC, CW, 3CXXC, DHHC, CXXC, CPXCG, CHCC, CHY, CTCHY, TRAF, FLZ, A20, AN1, C3HC, C2HC5, C5HC2, Dof, DNA-pol, SCA7, GCS, BTK, Tim10/DDP, DM, NF-X1 and XPA zinc finger.
Further, 56 different zinc finger motifs were grouped under the above-mentioned 32 different classes based on the zinc ion coordinating cysteine and histidine sequence motifs. For instance, CCHH (i.e. 2 cysteines followed by 2 histidine amino acids), CCHC, CCCH and CHHC motifs were grouped under C2H2 zinc finger. Similarly, zinc ribbon domain classification encompasses CCCC, CCCH and CHCC motifs. Notably, treble clef was sub-classified into 11 types and 17 sequence motifs were grouped under them.
