AagingBase | Database of anti-aging peptide

Peptide Card for AAPeptide281


The Peptide Card page for AAPeptide281 gives textual and graphical visualizations of the properties of AAPeptide281. The users can find all the literature informations collected from scholarly articles and patents and the calculated physicochemical informations. There are also graphical representations hydropathy values, amino acid compositions and frequencies, atomic compositions and secondary structure fractions of AAPeptide281.
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AAP IDAAPeptide281
Peptide nameNA
PubMed/Patent IDUS 11246818 B2
OriginSynthetic
Source of OriginNA
Condition addressedSkin aging
Experiment typeIn vitro, Ex vivo
Cell lines/Animal modelPrimary human epidermal keratinocytes, Primary human epidermal melanocytes
InterventionCells were treated with the peptide
Experiment methodsABTS decolorization assay, DPPH free radical scavenging assay, Thiobarbituric acid reactive substances (TBARS) assay, ELISA, Tyrosinase activity evaluation, MDA antioxidant enzyme activity, qRT-PCR
Patient groupHuman skin explants from a 49-year-old Caucasian woman
Markers usedCYP2R1, NFE2L2, HMOX1, GSTP1 , GSS , GPX1 and TRX
Mechanism of actionAddresses skin imperfections associated with oxidative-stress, such as, skin complexion, pigmentation alterations, wrinkling and loss in skin density, tone and elasticity due to reduced amount of collagen or elastic fibers, loss in the structure of the extracellular matrix or structural lipids or DNA damage, Increases skin fragility and inflammatory response
Molecular weight541.639
Peptide length4
Instability index0.775
Aromaticity0.500
Aliphaticity0.000
Reduced molecular extinction coeffecient0
Oxidized molecular extinction coeffecient0
Isoelectric point8.410
Composition of positively charged residues0.250
Composition of negatively charged residues0.000
Composition of neutral charged residues0.750
Composition of residues polar residues0.250
Composition of residues non-polar residues0.500
Composition of residues having cyclic side chain0.000
Composition of acidic residues0.000
Composition of basic residues0.250
Composition of residues having cyclic side chain0.000
Composition of hydroxylic residues0.250
Composition of residue in buried solvent accessibility0.500
Composition of residue in exposed solvent accessibility0.250
Composition of residue in intermediate solvent accessibility0.250

AAPeptide281 :
TFFK

Amino acid data
ProtScale


Disclaimer: Hydropathy plot is not available for AAPeptide281 as the peptide length is less than 9 amino acid residues

Atomic information


3D Structure

Structural Representation of AAPeptide281

Amino acid data
Secondary structure fraction