AagingBase | Database of anti-aging peptide

AagingBase: Database of anti-aging peptides A manually curated comprehensive database for anti-aging peptides

Peptide Card for AAPeptide225

The Peptide Card page for AAPeptide225 gives textual and graphical visualizations of the properties of AAPeptide225. The users can find all the literature informations collected from scholarly articles and patents and the calculated physicochemical informations. There are also graphical representations hydropathy values, amino acid compositions and frequencies, atomic compositions and secondary structure fractions of AAPeptide225.
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AAP ID	AAPeptide225
Peptide name	NA
PubMed/Patent ID	US 2021/0009637 A1
Origin	Natural
Source of Origin	Jelly fish (such as Chironex fleckeri), Sea anemone (such as Heteractis magnifica), Spider (such as Latrodectus mactans), Octopus (such as Hapalochlaena maculosa).
Condition addressed	Skin aging
Experiment type	In vitro
Cell lines/Animal model	Human fibroblast cell line (CCD-966SK)
Intervention	Cells were treated with the peptide
Experiment methods	Assay in increasing Expression of Genes
Patient group	NA
Markers used	NADSYN,Atg1, Ubl-5,FOXO,MRPS5, CCT2 and/or CCT8(Anti-aging gene), TERC(Telomerase genes), ERCC1,UNG, MSH6, XRCCS and/or MSH6(DNA repair genes), SMPD1,ELG-F and GBA(Moisture-retention related genes), collagen I gene, collagen IV gene, elastin genes, TIMP1, MMP-1
Mechanism of action	Inhibits collagen breakdown, Increases the production of collagen, elastin and/or hyaluronic acid, regarding aging, Improves skin and inhibits inflammation

Molecular weight	534.691
Peptide length	4
Instability index	-51.300
Aromaticity	0.250
Aliphaticity	0.250
Reduced molecular extinction coeffecient	0
Oxidized molecular extinction coeffecient	0
Isoelectric point	10.003
Composition of positively charged residues	0.500
Composition of negatively charged residues	0.000
Composition of neutral charged residues	0.500
Composition of residues polar residues	0.000
Composition of residues non-polar residues	0.500
Composition of residues having cyclic side chain	0.000
Composition of acidic residues	0.000
Composition of basic residues	0.500
Composition of residues having cyclic side chain	0.000
Composition of hydroxylic residues	0.000
Composition of residue in buried solvent accessibility	0.500
Composition of residue in exposed solvent accessibility	0.500
Composition of residue in intermediate solvent accessibility	0.000

AAPeptide225 :

KIFK

Amino acid data

ProtScale

Disclaimer: Hydropathy plot is not available for AAPeptide225 as the peptide length is less than 9 amino acid residues

Atomic information

3D Structure

Structural Representation of AAPeptide225

Amino acid data

Secondary structure fraction