AagingBase | Database of anti-aging peptide

AagingBase: Database of anti-aging peptides A manually curated comprehensive database for anti-aging peptides

Peptide Card for AAPeptide039

The Peptide Card page for AAPeptide039 gives textual and graphical visualizations of the properties of AAPeptide039. The users can find all the literature informations collected from scholarly articles and patents and the calculated physicochemical informations. There are also graphical representations hydropathy values, amino acid compositions and frequencies, atomic compositions and secondary structure fractions of AAPeptide039.
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AAP ID	AAPeptide039
Peptide name	MyD88 inhibitor
PubMed/Patent ID	EP 3366302 A1
Origin	Synthetic
Source of Origin	NA
Condition addressed	Age-related macular degeneration
Experiment type	In vitro, In vivo, Ex vivo
Cell lines/Animal model	Primary mouse RPE cells, HeLa cells, THP-1 cells, Wild-type C57BL/6J mice
Intervention	Cells were transfected with plasmid containing peptide siRNA sense, Subretinal injections of the peptide in mice
Experiment methods	Immunostaining, Western blot, MTS Cell viability and cytotoxicity assay, H2DCF DA ROS assay, RNA-binding protein immunoprecipitation (RIP), ELISA, Caspase-8 activity assessment
Patient group	Donor eyes or ocular tissues from patients with geographic atrophy due to AMD or age-matched patients without AMD
Markers used	NA
Mechanism of action	Cell protection

Molecular weight	3100.647
Peptide length	24
Instability index	49.329
Aromaticity	0.125
Aliphaticity	0.250
Reduced molecular extinction coeffecient	11000
Oxidized molecular extinction coeffecient	11000
Isoelectric point	11.580
Composition of positively charged residues	0.333
Composition of negatively charged residues	0.083
Composition of neutral charged residues	0.583
Composition of residues polar residues	0.125
Composition of residues non-polar residues	0.417
Composition of residues having cyclic side chain	0.042
Composition of acidic residues	0.083
Composition of basic residues	0.333
Composition of residues having cyclic side chain	0.042
Composition of hydroxylic residues	0.042
Composition of residue in buried solvent accessibility	0.333
Composition of residue in exposed solvent accessibility	0.417
Composition of residue in intermediate solvent accessibility	0.125

AAPeptide039 :

DRQIKIWFQNRRMKWKKRDVLPGT

Amino acid data

ProtScale

Atomic information

3D Structure

Structural Representation of AAPeptide039

Amino acid data

Secondary structure fraction