AagingBase | Database of anti-aging peptide

AagingBase: Database of anti-aging peptides A manually curated comprehensive database for anti-aging peptides

Peptide Card for AAPeptide028

The Peptide Card page for AAPeptide028 gives textual and graphical visualizations of the properties of AAPeptide028. The users can find all the literature informations collected from scholarly articles and patents and the calculated physicochemical informations. There are also graphical representations hydropathy values, amino acid compositions and frequencies, atomic compositions and secondary structure fractions of AAPeptide028.
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AAP ID	AAPeptide028
Peptide name	Pep-WH-12
PubMed/Patent ID	US 2018/0134749 A12,EP 3305802 A1,US 10676507 B2
Origin	Synthetic
Source of Origin	NA
Condition addressed	Skin aging
Experiment type	In vitro, In vivo
Cell lines/Animal model	Human acute monocytic leukemia cell line (THP1), HepG2 cell line, Sprague-Dawley (SD) rats
Intervention	Treated with the peptide(in the medium),Cells were treated with the peptide, A wound-induced animal model was treated with each of the novel peptides,
Experiment methods	HPLC, Western blot, ELISA
Patient group	NA
Markers used	pSmad2/3 , Smad2/3 , GAPDH ,pSmad2/3 and Smad2/3 (TGF-β signaling activity markers)
Mechanism of action	Anti-inflammation, Anti-fibrosis, Wound healing, Anti-cancer treatment, Improves skin condition

Molecular weight	935.121
Peptide length	8
Instability index	22.213
Aromaticity	0.125
Aliphaticity	0.375
Reduced molecular extinction coeffecient	0
Oxidized molecular extinction coeffecient	0
Isoelectric point	11.001
Composition of positively charged residues	0.250
Composition of negatively charged residues	0.000
Composition of neutral charged residues	0.750
Composition of residues polar residues	0.250
Composition of residues non-polar residues	0.500
Composition of residues having cyclic side chain	0.000
Composition of acidic residues	0.000
Composition of basic residues	0.250
Composition of residues having cyclic side chain	0.000
Composition of hydroxylic residues	0.250
Composition of residue in buried solvent accessibility	0.500
Composition of residue in exposed solvent accessibility	0.125
Composition of residue in intermediate solvent accessibility	0.250

AAPeptide028 :

ALTSKLRF

Amino acid data

ProtScale

Disclaimer: Hydropathy plot is not available for AAPeptide028 as the peptide length is less than 9 amino acid residues

Atomic information

3D Structure

Structural Representation of AAPeptide028

Amino acid data

Secondary structure fraction