The AMLDB database is a comprehensive resource that provides researchers with access to a wealth of data related to acute myeloid leukemia (AML). It provides access to expression and methylation profiles of patient data along with their clinical characteristics from microarray and RNA-seq experiments carried out in different platfoems like Affymetrix, Illumina and Agilent. Genome-wide CRISPR-Cas9 screen data to understand cancer vulnerabilities and drug-mutational data to identify mutations that may be driving AML, effecting the response to drugs have also been incorporated. The database accomodates information published till January 2023 and are available for download. Website can be accessed via:AMLdb
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Expression profiling: A technique used to measure the activity of genes in a particular tissue or cell type.
Methylation profiling: A method used to study the epigenetic modifications that occur in DNA, particularly the addition or removal of methyl groups.
CRISPR-Cas9: A type of genetic engineering technology used to edit genes in a targeted manner, which has become a powerful tool for studying gene function.
Drug-mutation data: A dataset that links specific genetic mutations with the response to different drugs or therapies.
GEO (Gene Expression Omnibus): A public repository for gene expression and other molecular biology data.
GDSC (Genomics of Drug Sensitivity in Cancer): A resource that provides information on the response of cancer cells to different drugs.
Project Achilles: A project hosted at DepMap, that uses CRISPR-Cas9 gene editing to identify cancer vulnerabilities.
COSMIC (Catalogue of Somatic Mutations in Cancer): A database of somatic mutations that occur in cancer cells, which is used to study the genetic basis of cancer.
Developer:
Ms. Keerthana Vinod Kumar
M.Tech Medical Biotechnology
Department of Biotechnology
Indian Institute of Technology Hyderabad
For any enquiries email:
keerthanavinod@gmail.com
Principal Investigator:
Dr. Rahul Kumar
Assistant Professor
Department of Biotechnology
Indian Institute of Technology Hyderabad
For any enquiries email:
rahulk@bt.iith.ac.in
Location:
BT-321, BTBM Building
Computational genomics and transcriptomics lab
Department of Biotechnology
Indian Institute of Technology Hyderabad
For any enquiries email:
keerthanavinod@gmail.com
Data usage: All data available can be used for non-commercial purpose only.
Citation: Kindly give credit to AMLdb in your publications by referencing the following sources:
AMLdb: A comprehensive multi-omics platform to understand pathogenesis and to discover potential biomarkers and drug targets for Acute Myeloid Leukemia.
Keerthana Vinod Kumar, Ambuj Kumar,Kavita Kundal, Avik Sengupta, Kunjulakshmi R, Rahul Kumar
Disclaimer: AMLdb is a database for acute myeloid leukemia designed to provide comprehensive information on the disease. However, the information provided in AMLdb is not intended to replace medical advice or treatment from a qualified healthcare professional. Users of AMLdb should exercise their own discretion and judgment in the interpretation and use of the information provided. AMLdb is not responsible for any consequences resulting from the use of the information provided in the database.