eVGeMdb

Genetic Modifiers: Genes that can affect the phenotypic expression of primary disease-causing genes.

Target Gene/Protein: The primary gene or protein whose function or dysfunction is associated with the disease, (e.g., TDP-43 in ALS, A-beta in Alzheimer’s).

Disease Model: The experimental system (e.g., cell line, yeast, worm, mice) used to identify genetic modifiers.

Phenotype: The biological outcome observed in the disease model due to altered modifier genes.

Screen: The experimental strategies used to modify candidate modifier genes.

Type of Modification: The event caused in the modifier gene to see its effect.

Effect: Direction of modification: Suppression (reduces toxicity), Enhancement (increases toxicity),

Suppression: As per the designed experiment, the modifier gene shows the reduction of the disease phenotype.

Enhancement: As per the designed experiment, the modifier gene shows the increased disease phenotype.

Human Ortholog: Human gene corresponding to the modifier gene.

Targeted Drugs: Drugs from DrugBank that target the human ortholog of the modifier genes.

PMID : PubMed ID of the publication from which this modifier was curated.