3D-NuS-Qplex

Quadruplexes are four-stranded secondary structures formed by guanine-rich sequences in DNA or RNA, which play important roles in diverse biological processes. 3D-Nus-Qplex (3-Dimensional Nucleic Acid Structures - Quadruplex) is a specialized web tool designed for the modeling and visualization of 3-dimensional structures of all theoretically possible nucleic acid quadruplexes. This platform currently supports the automated generation of 200 quadruplex structures, including 48 monomers, 96 dimers, 48 trimers, and 8 tetramers. The structures modelled can represent both DNA and RNA sequences, with options to include overhangs and non-G-quartet residues.

3D-Nus-Qplex generates energy-minimized models that serve as valuable starting points for molecular docking, dynamic simulations, and other computational studies, enabling researchers to better understand the behavior and interactions of quadruplex structures. Understanding the 3D structure of nucleic acid quadruplexes is crucial, as these structures play significant roles in gene regulation, genome stability, and potential therapeutic targeting. Insights into their spatial arrangement help in designing selective ligands for drug development, exploring their roles in biological processes, and constructing nanoscale molecular devices. By offering reliable 3D models, ​3D-Nus-Qplex empowers scientists to investigate the structural and functional implications of quadruplexes with precision and ease.